Research groups at the Laboratory for Molecular Infection Medicine Sweden (MIMS).
The Read More link lead to the researchers personal homepage.
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Bacteria-host interactions |
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Our research is aimed at increasing the understanding of the mechanisms by which pathogenic /E. coli/ and other enterobacteria express virulence-associated properties. We study molecular mechanisms behind expression and function of genes and gene products that contribute to the bacterial interactions with host environments.
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PI: Bernt Eric Uhlin
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Pathogenesis, antigenic variation and genetic organization |
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The overall aim of this project is to gain an increased knowledge of the virulence properties of Borrelia spirochetes. We will continue the basic research on the mechanisms of antigenic variation of Borrelia and to characterise and define the components involved in the interactions between RF Borrelia and erythrocytes as well as the effect(s) that the erythrocyte rosetting exhibit at the cellular and molecular level in the mammalian host. We will also investigate what molecules that are involved in the interactions employed by B. burgdorferi s.l., the Lyme disease agent, with different mammalian cells and tissues. As well as structural and functional studies on those outer surface located molecules.
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PI: Sven Bergström
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Helicobacter pylori |
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Helicobacter pylori infection causes chronic active gastritis and peptic ulcer disease. In the western world, 10% of people (22.000.000 individuals) develop peptic ulcers. Furthermore, H. pylori infection is tightly correlated with development of gastric cancer with >500.000 mortalities/Y and, H. pylori has been defined a carcinogen by the WHO. The project studies protein-carbohydrate interactions that mediate adherence of H. pylori to stomach tissue. We focus on the Blood Group Antigen Binding Adhesin, BabA, which is the key player attachment protein that targets H. pylori binding to the stomach lining.
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PI: Thomas Borén
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Development of new diagnostic tools for infectious diseases |
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Diagnosis of tularemia tradionally relies on cultivation, PCR and serology, but there is still a need to improve the diagnostic possibilities, e.g., with regard to speed and prognostic markers. Moreover, some patients present with uncharacteristic symptoms and are therefore difficult to diagnose. The relatively high number of samples handled by the laboratory means that the laboratory staff may be exposed to the bacterium during routine work and since it is highly contagious, being at risk to contract tularemia. Therefore, improved assays that allow very rapid diagnosis are of high priority. We will now develop methods based on the characterization of the host response or secreted bacterial factors as rapid diagnostic tools that also can have prognostic potential. Moreover, we will develop very rapid methods for identification and typing of the bacterium to enhance the laboratory safety.
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PI: Anders Sjöstedt
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The Type III secretion system of pathogenic Yersinia |
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There are three human pathogenic strains of Yersinia; Y.pestis , Y.pseudotuberculosis and Y.enterocolitica . Y.pestis is the causative agent of plague; and was responsible for the Black death during the 14th century. This family of bacteria harbours a common virulence plasmid which encodes a number of secreted proteins collectively called Yops (Yersinia outer proteins). These proteins are expressed during infection and they are major antihost factors.
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PI: Hans Wolf-Watz
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RNA-mediated virulence regulation |
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PI: Jörgen Johansson
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The intracellular pathogen Listeria monocytogenes has turned out to be a very important model for the study of host-pathogen interactions and bacterial adaptation to mammalian hosts.
We are studying different aspects of RNA-mediated virulence gene regulation in L. monocytogenes. By using different approaches, we identified several ncRNAs in the human bacterial pathogen Listeria monocytogenes. Several of them are involved in virulence by controlling different steps in the infection process, and their exact mechanism is currently being studied.
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Virus-host interactions |
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In our project we are identifying and characterizing molecules and molecular mechanisms that regulate virus binding to host cells. We focus on adenoviruses, picornaviruses and to some extent influenza A virus. A major goal of our research is to define target mechanisms for antiviral treatment.
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PI: Nilklas Arnberg
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dNTPs as cellular regulators |
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Genetic information in most organisms is stored as DNA. DNA is synthesized from four building blocks, dNTPs. The DNA is constantly damaged either spontaneously or by environmental agents. If the damaged DNA is not repaired, it acquires mutations. Some mutations may cause genetic instability and cancer.
In eukaryotes, DNA damage leads to arrest of cell cycle, transcriptional activation of DNA repair genes, and apoptosis. These responses allow cells to survive the damage and repair the DNA.
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PI: Andrei Chabes
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Antifungal immunity |
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Our group "Antifungal Immunity" is interested in the fundamental processes during infections with pathogenic fungi. We combine studies on how the innate immune system restricts the spread of fungal pathogens and how these microbes in turn react to the host environment.
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PI: Constantin Urban
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Molecular mechanisms governing gram-positive bacterial pathogenesis |
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Our group is interested in the understanding of molecular mechanisms governing the interaction of gram-positive pathogens with their hosts, employing the human pathogen Streptococcus pyogenes (Group A streptococcus, GAS) as a model organism. During an ongoing disease process, pathogens are heavily exposed to different specific and non-specific host defence mechanisms, amongst others growth-limiting conditions and stress factors at the site of infection. To thrive under these hostile conditions, pathogenic bacteria have developed well-directed strategies leading to a coordinated expression of virulence factors in response to host-induced environmental changes. In this regard, small regulatory RNA molecules and regulated proteolysis play key roles in gram-positive bacterial pathogenesis and constitute the current research focus of our lab.
 Job Opportunities in the Lab of Emmanuelle Charpentier
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PI: Emmanuelle Charpentier
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