New findings reveal a hitherto unrecognised feature of bacterial membrane vesicles that are mimicking eukaryotic exosomes and contain RNA that can be delivered to host tissues and cells. Professor Sun Nyunt Wai and colleagues at MIMS and Department of Molecular Biology, Umeå University, are reporting that RNA can be found in bacterial membrane vesicles. This discovery highlights the potential role of RNA-containing bacterial membrane vesicles to be involved in bacteria-host interactions.
The findings are published in the latest issue of Scientific Reports-Nature Publishing Group.
Authors are Annika Sjöström, Linda Sandblad, Bernt Eric Uhlin, Sun Nyunt Wai.
Annika E. Sjöström, Linda Sandblad, Bernt Eric Uhlin & Sun Nyunt Wai (2015): Membrane vesicle-mediated release of bacterial RNA. Scientific Reports 5:15329; DOI: 10.1038/srep15329. Published Online 2015-10-20.
Picture: Cryo-electron tomogram of purified vesicles. Original published in Scientific Reports.
Our immune system is vital to us and can sometimes overreact causing chronic illnesses, such as for instance rheumatism and allergy. Now, researchers from Umeå University and University of Gothenburg have identified a molecular switch – MYSM1 – that can suppress such an overreaction and avoid inflammation. The study is published in the prestigious journal Immunity.
“The discovery of MYSM1 is a major milestone in our understanding of how our immune system works, and how its response could be controlled in order to prevent inflammatory diseases such as sepsis,” says Nelson O. Gekara, research leader at MIMS, Molecular Infection Medicine Sweden at Umeå University.
Welcome to the University's EC Jubiliee Symposium!
Friday 16 October Aula Nordica, 13.30-16.30
“What enables groundbreaking research? What might attract the next generation of researchers? These questions are of fundamental importance to research and will be highlighted and discussed at the symposium Excellence by Choice.
Invited speakers include internationally leading scientists and research directors involved in recruitment and scientific policy guiding. Young group leader colleagues share their experience together with the successful MIMS group leader and role model Emmanuelle Charpentier, now known worldwide for her research on CRISPR-Cas9, a groundbreaking genome editing tool. The symposium is organised by Umeå University and its Laboratory for Molecular Infection Medicine Sweden – MIMS – the Swedish node in The Nordic EMBL Partnership for Molecular Medicine.
Find more information and biographies of the speakers on the Website of Umeå University: www.umu.se/excellence-by-choice
Umeå university scientists have shown how mast cells, immune cells typically associated with allergy and asthma, act as sentinels to orchestrate the immune response against the fungus Candida albicans the leading cause of fungal vaginitis. Vaginitis is a common women´s health concern affecting 75% of women at some time in their lives. Getting a grip on how the body senses the entry of fungal pathogens offers major opportunities for designing new strategies to improve women´s health. Details can be found in a recent research report published in the prestigious journal Nature Scientific Reports.