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Arvid EdenCentral nervous system viral ”escape” and neuronal damage in HIV-1 infection

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Infectious Diseases, Institute of Biomedicine,
Sahlgrenska Academy, University of Gothenburg

Antiretroviral therapy (ART) has had a major impact in reducing HIV-1 related disease in the CNS, including HIV-associated dementia, but milder forms of neurocognitive impairment remains prevalent.

Although ART is usually effective in lowering HIV-1 RNA in cerebrospinal fluid (CSF) as well as in plasma, cases of viral "escape" in CSF have been described.

We have previously shown that 10% of effectively treated patients had detectable levels of HIV-1 RNA in CSF despite having undetectable levels in plasma, suggesting that some individuals may have a continuous low grade CNS infection.

Our current research project will evaluate the occurrence of detectable CSF HIV-1 RNA longitudinally, in relation to immune activation and neuronal damage.

Emmanuelle Charpentier took the Nobel Prize in Chemistry

Emmanuelle has been awarded jointly with Jennifer Doudna the 2020 Nobel Prize in Chemistry for discovering the groundbreaking CRISPR-Cas9 gene editing technology. She is a former group leader at MIMS, honorary doctor at Umeå University and former visiting professor at UCMR.

Movie by Knut and Alice Wallenberg Foundation (

Battling antibiotic resistance

movie by Knut and Alice Wallenberg Foundation, with participation of scientists from MIMS and UCMR:
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Research about infectious diseases:

Oliver Billker in movie of Knut and Alice Wallenberg Foundation:
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