UMU logo

Peter BergmanVitamin D and human immunity - experimental and clinical studies

This email address is being protected from spambots. You need JavaScript enabled to view it.
Clinical Microbiology, Virology, Karolinska University Hospital,
Huddinge, Stockholm
Webpage at Karolinska University Hospital

Vitamin D regulates calcium balance and bone health. In addition, it has a key role in adaptive and innate immunity. Low serum-levels of vitamin D is associated with an increased risk of respiratory tract infections.

We hypothesized that vitamin D supplementation could reduce the frequency and severity of respiratory tract infections (RTIs). To test this hypothesis we performed a randomised and placebo-controlled trial where 4000 IU vitamin D3 or placebo was given to patients for one year.

The main result was that patients given vitamin D exhibited a reduced infectious burden related to RTIs and a lower antibiotic consumption compared with the placebo-group. Interestingly, in vitro experiments have shown that another compound, phenylbutyrate (PBA), is able to potentiate the effects of vitamin D.

Thus, the combination of Vitamin D and PBA could potentially have even better clinical effects than vitamin D alone. My current research focus is to study the mechanisms involved in Vitamin D/PBA mediated effects on immunity and to perform additional clinical trials.

Emmanuelle Charpentier took the Nobel Prize in Chemistry

Emmanuelle has been awarded jointly with Jennifer Doudna the 2020 Nobel Prize in Chemistry for discovering the groundbreaking CRISPR-Cas9 gene editing technology. She is a former group leader at MIMS, honorary doctor at Umeå University and former visiting professor at UCMR.

Movie by Knut and Alice Wallenberg Foundation (

Battling antibiotic resistance

movie by Knut and Alice Wallenberg Foundation, with participation of scientists from MIMS and UCMR:
Or watch the original movie on:

Research about infectious diseases:

Oliver Billker in movie of Knut and Alice Wallenberg Foundation:
Or watch the original movie on:

footer all slides 2014-02-06

Copyright © 2019 by The Laboratory for Molecular Infection Medicine Sweden (MIMS). All rights reserved.