Vitamin D and human immunity - experimental and clinical studies
Clinical Microbiology, Virology, Karolinska University Hospital,
Webpage at Karolinska University Hospital
Vitamin D regulates calcium balance and bone health. In addition, it has a key role in adaptive and innate immunity. Low serum-levels of vitamin D is associated with an increased risk of respiratory tract infections.
The main result was that patients given vitamin D exhibited a reduced infectious burden related to RTIs and a lower antibiotic consumption compared with the placebo-group. Interestingly, in vitro experiments have shown that another compound, phenylbutyrate (PBA), is able to potentiate the effects of vitamin D.
Thus, the combination of Vitamin D and PBA could potentially have even better clinical effects than vitamin D alone. My current research focus is to study the mechanisms involved in Vitamin D/PBA mediated effects on immunity and to perform additional clinical trials.