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Mechanisms and dynamics of endocytic carrier formation during infection
PI: Richard Lundmark, Associate Professor
Department of Medical Biochemistry and Biophysics
Endocytosis is the way by which cells take up nutrients, regulate cell surface receptors and control membrane rearrangements during migration. During endocytosis, distinct protein machineries re-sculpture the plasma membrane into vesicular or tubular membrane carriers that enclose molecules that are to be taken up into the cell. Besides the canonical clathrin endocytic machinery, it is becoming increasingly clear that additional membrane carriers exist for the delivery of a variety of proteins, including integrins, GPI-anchored receptors, viruses and bacterial toxins. Effector molecules secreted by bacteria are designed to specifically target cellular processes. Such molecules have been shown to facilitate their own uptake into cells. Similarly, viruses can easily hijack endocytic pathways of the cell due to their relatively small size.
Morén et al Mol Biol Cell. (2012)
Doherty and Åhlund M et al Mol Biol Cell. (2011)
Howes M. et al. J Cell Biol. (2010).
Lundmark R, et al. Curr Biol. 18, (2008).
Daumke O and Lundmark R, et al. Nature 449, (2007).
Pylypenco et al. EMBO J. (2007)
We use a multidisciplinary approach including biochemical analysis, structural determination and advanced imaging. Our biochemical methodology is supported by a protein purification platform and excellent equipment for assaying protein and lipid interactions. We run a national infrastructure for dynamic live cell confocal microscopy. This spectral confocal microscope system is combined live cell incubation and micromanipulation systems, fully equipped for extremely sensitive high-speed detection, full spectral resolution, TIRF microscopy and photo-bleaching (FRAP) and photo-quenching (FRET) experiments. This system is in addition equipped with a STORM-unit capable of ultra-resolution imaging. In addition, we use electronmicroscopy and AFM for ultra-structural studies.
Our lab is situated in the Chemistry and Biology Centre (KBC) at Umeå University and belongs to the MIMS (The Laboratory for Molecular Infection Medicine Sweden - MIMS within the Nordic EMBL Partnership for Molecular Medicine). The KBC and MIMS environments offer state-of-the-art facilities for biological sciences and modern laboratories in a creative, inspiring and highly interactive environment.
Web page Richard Lundmark at the Department of Medical Biochemistry and Biophysics
Swedish summary on the research of Richard Lundmark's group (www.umu.se)