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Publications of the Sjöstedt Group

Rzhepishevska, O., Limanska, N., Galkin, M., Lacoma, A., Lundquist, M., Sokol, D., Hakobyan, S., Sjostedt, A., Prat, C. and Ramstedt, M. (2018) Characterization of clinically relevant model bacterial strains of Pseudomonas aeruginosa for anti-biofilm testing of materials. Acta Biomater 76, 99-107.

Eneslatt, K., Golovliov, I., Ryden, P. and Sjostedt, A. (2018) Vaccine-Mediated Mechanisms Controlling Replication of Francisella tularensis in Human Peripheral Blood Mononuclear Cells Using a Co-culture System. Front Cell Infect Microbiol 8, 27.

Alam, A., Golovliov, I., Javed, E. and Sjostedt, A. (2018) ClpB mutants of Francisella tularensis subspecies holarctica and tularensis are defective for type VI secretion and intracellular replication. Sci Rep 8(1), 11324.

Wallet, P., Benaoudia, S., Mosnier, A., Lagrange, B., Martin, A., Lindgren, H., Golovliov, I., Michal, F., Basso, P., Djebali, S., Provost, A., Allatif, O., Meunier, E., Broz, P., Yamamoto, M., Py, B.F., Faudry, E., Sjostedt, A. and Henry, T. (2017) IFN-gamma extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. PLoS Pathog 13(10), e1006630.

Honn, M., Lindgren, H., Bharath, G.K. and Sjostedt, A. (2017) Lack of OxyR and KatG Results in Extreme Susceptibility of Francisella tularensis LVS to Oxidative Stress and Marked Attenuation In vivo. Front Cell Infect Microbiol 7, 14.

Bröms, J.E., Meyer, L. and Sjöstedt, A. (2017) A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control Type VI system-mediated secretion. Virulence 8(6), 821-847.

Rigard, M., Broms, J.E., Mosnier, A., Hologne, M., Martin, A., Lindgren, L., Punginelli, C., Lays, C., Walker, O., Charbit, A., Telouk, P., Conlan, W., Terradot, L., Söstedt, A. and Henry, T. (2016) Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence. Plos Pathogens 12(9).

Rigard, M., Bröms, J., Mosnier, A., Hologne, M., Martin, A., Lays, C., Lindgren, L., Punginelli, C., Walker, O., Charbit, A., Telouk, P., Conlan, W., Terradot, L., Sjöstedt, A. and Henry, T. (2016) IglG belongs to a novel family of PAAR-like T6SS proteins and harbors a unique N terminal extension required for Francisella virulence. Plos Pathogens.

Ozanic, M., Marecic, V., Lindgren, M., Sjostedt, A. and Santic, M. (2016) Phenotypic characterization of the Francisella tularensis DeltapdpC and DeltaiglG mutants. Microbes Infect 18(12), 768-776.

Lindgren, H. and Sjöstedt, A. (2016) Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis. Antimicrob Agents Chemother 60(1), 288-295.

Larson, M.A., Nalbantoglu, U., Sayood, K., Zentz, E.B., Cer, R.Z., Iwen, P.C., Francesconi, S.C., Bishop-Lilly, K.A., Mokashi, V.P., Sjostedt, A. and Hinrichs, S.H. (2016) Reclassification of Wolbachia persica as Francisella persica comb. nov and emended description of the family Francisellaceae. International Journal of Systematic and Evolutionary Microbiology 66(3), 1200-1205.

Lampe, E.O., Brenz, Y., Herrmann, L., Repnik, U., Griffiths, G., Zingmark, C., Sjostedt, A., Winther-Larsen, H.C. and Hagedorn, M. (2016) Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum. Applied and Environmental Microbiology 82(5), 1586-1598.

Kauppi, A.M., Edin, A., Ziegler, I., Molling, P., Söstedt, A., Gylfe, Å., Stralin, K. and Johansson, A. (2016) Metabolites in Blood for Prediction of Bacteremic Sepsis in the Emergency Room. Plos One 11(1).

Golovliov, I., Lindgren, H., Eneslaett, K., Conlan, W., Mosnier, A., Henry, T. and Sjoestedt, A. (2016) An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy. Frontiers in Cellular and Infection Microbiology 6.

Desvars-Larrive, A., Liu, X., Hjertqvist, M., Sjöstedt, A., Johansson, A. and Rydén, P. (2016) High-risk regions and outbreak modelling of tularemia in humans. Epidemiol Infect 145(3), 482-490.

Meyer, L., Broms, J.E., Liu, X., Rottenberg, M.E. and Sjotedt, A. (2015) Microinjection of Francisella tularensis and Listeria monocytogenes Reveals the Importance of Bacterial and Host Factors for Successful Replication. Infection and Immunity 83(8), 3233-3242.

Lindgren, H., Lindgren, L., Golovliov, I. and Sjostedt, A. (2015) Mechanisms of Heme Utilization by Francisella tularensis. Plos One 10(3).

Lampe, E.O., Brenz, Y., Herrmann, L., Repnik, U., Griffiths, G., Zingmark, C., Sjostedt, A., Winther-Larsen, H.C. and Hagedorn, M. (2015) Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum. Appl Environ Microbiol 82(5), 1586-1598.

Edin, A., Granholm, S., Koskiniemi, S., Allard, A., Sjostedt, A. and Johansson, A. (2015) Development and Laboratory Evaluation of a Real-Time PCR Assay for Detecting Viruses and Bacteria of Relevance for Community-Acquired Pneumonia. Journal of Molecular Diagnostics 17(3), 315-324.

Desvars, A., Furberg, M., Hjertqvist, M., Vidman, L., Sjostedt, A., Ryden, P. and Johansson, A. (2015) Epidemiology and Ecology of Tularemia in Sweden, 1984-2012. Emerging Infectious Diseases 21(1), 32-39.

Binesse, J., Lindgren, H., Lindgren, L., Conlan, W. and Sjöstedt, A. (2015) Roles of reactive oxygen species-degrading enzymes of Francisella tularensis SCHU S4. Infect Immun 83(6), 2255-2263.

Sun, K., Broms, J., Lavander, M., Gurram, B.K., Enquist, P.-A., Andersson, C.D., Elofsson, M. and Sjostedt, A. (2014) Screening for Inhibition of Vibrio cholerae VipA-VipB Interaction Identifies Small-Molecule Compounds Active against Type VI Secretion. Antimicrobial Agents and Chemotherapy 58(7), 4123-4130.

Parkinson, A.J., Evengard, B., Semenza, J.C., Ogden, N., Borresen, M.L., Berner, J., Brubaker, M., Sjöstedt, A., Evander, M., Hondula, D.M., Menne, B., Pshenichnaya, N., Gounder, P., Larose, T., Revich, B., Hueffer, K. and Albihn, A. (2014) Climate change and infectious diseases in the Arctic: establishment of a circumpolar working group. Int J Circumpolar Health 73, 25163.

Lindgren, M., Tancred, L., Golovliov, I., Conlan, W., Twine, S.M. and Sjostedt, A. (2014) Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4. Infect Immun 82(9), 3622-3635.

De Pascalis, R., Chou, A.Y., Ryden, P., Kennett, N.J., Sjöstedt, A. and Elkins, K.L. (2014) Models Derived from In Vitro Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the Francisella tularensis Live Vaccine Strain (LVS). Mbio 5(2).

Vonkavaara M, Pavel ST, Hölzl K, Nordfelth R, Sjöstedt A and Stöven S (2013). Francisella is sensitive to insect antimicrobial peptides. J Innate Immun, 5 (1): 50-59.
PubMed Link

Rydén P, Twine S, Shen H, Harris G, Chen W, Sjöstedt A and Conlan W (2013). Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria. Mol Immunol, 54 (1): 58-67.
PubMed Link

Lindgren M, Bröms JE, Meyer L, Golovliov I and Sjöstedt A (2013). The Francisella tularensis LVS DeltapdpC mutant exhibits a unique phenotype during intracellular infection. BMC Microbiol, 13 20.
PubMed Link

Widerström M, Wiström J, Sjöstedt A, Monsen T (2012)
Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus
Eur J Clin Microbiol Infect Dis 31 (1): 7-20
PubMed Link

Twine S, Shen H, Harris G, Chen W, Sjöstedt A, Rydén P, Conlan W (2012)
BALB/c mice, but not C57BL/6 mice immunized with a DeltaclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: Association of protection with post-vaccination and post-challenge immune responses
Vaccine 30 (24): 3634-3645
PubMed Link

Rydén P, Björk R, Schäfer ML, Lundström JO, Petersen B, Lindblom A, Forsman M, Sjöstedt A, Johansson A (2012)
Outbreaks of tularemia in a boreal forest region depends on mosquito prevalence
J Infect Dis 205 (2): 297-304
PubMed Link

Ishikawa T, Sabharwal D, Bröms J, Milton DL, Sjöstedt A, Uhlin BE, Wai SN (2012)
Pathoadaptive conditional regulation of the type VI secretion system in Vibrio cholerae O1 strains
Infect Immun 80 (2): 575-584
PubMed Link

Honn M, Lindgren H, Sjöstedt A (2012)
The role of MglA for adaptation to oxidative stress of Francisella tularensis LVS
BMC Microbiol 12 14
PubMed Link

Eneslätt K, Normark M, Björk R, Rietz C, Zingmark C, Wolfraim LA, Stöven S, Sjöstedt A (2012)
Signatures of T cells as correlates of immunity to Francisella tularensis
PLoS One 7 (3): e32367
PubMed Link

Bröms JE, Meyer L, Lavander M, Larsson P, Sjöstedt A (2012)
DotU and VgrG, core components of type VI secretion systems, are essential for Francisella LVS pathogenicity
PLoS One 7 (4): e34639
PubMed Link

Tancred L, Telepnev MV, Golovliov I, Andersson B, Andersson H, Lindgren H, Sjöstedt A (2011)
Administration of a nitric oxide donor inhibits mglA expression by intracellular Francisella tularensis and counteracts phagosomal escape and subversion of TNF-alpha secretion
J Med Microbiol 60 (Pt 11): 1570-1583
PubMed Link

Sjöstedt A (2011)
Special Topic on Francisella tularensis and Tularemia
Front Microbiol 2 86
PubMed Link

Rzhepishevska O, Ekstrand-Hammarström B, Popp M, Björn E, Bucht A, Sjöstedt A, Antti H, Ramstedt M (2011)
The antibacterial activity of Ga3+ is influenced by ligand complexation as well as the bacterial carbon source
Antimicrob Agents Chemother 55 (12): 5568-5580
PubMed Link

Lindgren H, Honn M, Salomonsson E, Kuoppa K, Forsberg A, Sjöstedt A (2011)
Iron content differs between Francisella tularensis subspecies tularensis and subspecies holarctica strains and correlates to their susceptibility to H(2)O(2)-induced killing
Infect Immun 79 (3): 1218-1224
PubMed Link

Kelk P, Abd H, Claesson R, Sandström G, Sjöstedt A, Johansson A (2011)
Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin
Cell Death Dis 2 e126
PubMed Link

Fulton KM, Zhao X, Petit MD, Kilmury SL, Wolfraim LA, House RV, Sjostedt A, Twine SM (2011)
Immunoproteomic analysis of the human antibody response to natural tularemia infection with Type A or Type B strains or LVS vaccination
Int J Med Microbiol 301 (7): 591-601
PubMed Link

Eneslätt K, Rietz C, Rydén P, Stöven S, House RV, Wolfraim LA, Tärnvik A, Sjöstedt A (2011)
Persistence of cell-mediated immunity three decades after vaccination with the live vaccine strain of Francisella tularensis
Eur J Immunol 41 (4): 974-980
PubMed Link

Bröms JE, Lavander M, Meyer L, Sjöstedt A (2011)
IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS
Infect Immun 79 (9): 3683-3696
PubMed Link

Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W (2010)
Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy
PLoS One 5 (10): e13349
PubMed Link

Forslund AL, Salomonsson EN, Golovliov I, Kuoppa K, Michell S, Titball R, Oyston P, Noppa L, Sjöstedt A, Forsberg A (2010)
The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis
BMC Microbiol 10 227
PubMed Link

Elfving K, Olsen B, Bergström S, Waldenström J, Lundkvist A, Sjöstedt A, Mejlon H, Nilsson K (2010)
Dissemination of spotted fever rickettsia agents in Europe by migrating birds
PLoS One 5 (1): e8572
PubMed Link

Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A (2010)
Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization
Vaccine 28 (7): 1824-1831
PubMed Link

Bröms JE, Sjöstedt A, Lavander M (2010)
The role of the Francisella tularensis pathogenicity island in type VI secretion, intracellular survival, and modulation of host cell signaling
Front Microbiol 1 136
PubMed Link

Åhlund MK, Ryden P, Sjöstedt A, Stöven S (2010)
Directed screen of Francisella novicida virulence determinants using Drosophila melanogaster
Infect Immun 78 (7): 3118-3128
PubMed Link

Salomonsson E, Kuoppa K, Forslund A, Zingmark C, Golovliov I, Sjöstedt A, Noppa L, Forsberg A (2009)
Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis
Infect Immun 77 (8): 3424-3431
PubMed Link

Rydén P, Sjöstedt A, Johansson A (2009)
Effects of climate change on tularaemia disease activity in Sweden
Glob Health Action 2 /> PubMed Link

Lindgren H, Honn M, Golovlev I, Kadzhaev K, Conlan W, Sjöstedt A (2009)
The 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of iron
Infect Immun 77 (10): 4429-4436
PubMed Link

Kadzhaev K, Zingmark C, Golovliov I, Bolanowski M, Shen H, Conlan W, Sjöstedt A (2009)
Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model
PLoS One 4 (5): e5463
PubMed Link

Champion MD, Zeng Q, Nix EB, Nano FE, Keim P, Kodira CD, Borowsky M, Young S, Koehrsen M, Engels R, Pearson M, Howarth C, Larson L, White J, Alvarado L, Forsman M, Bearden SW, Sjostedt A, Titball R, Michell SL, Birren B, Galagan J (2009)
Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies
PLoS Pathog 5 (5): e1000459
PubMed Link

Vonkavaara M, Telepnev M, Rydén P, Sjöstedt A, Stöven S (2008)
Drosophila melanogaster as a model for elucidating the pathogenicity of Francisella tularensis
Cell Microbiol 10 (6): 1327-1338
PubMed Link

Tano K, von Essen R, Eriksson PO, Sjöstedt A (2008)
Alloiococcus otitidis--otitis media pathogen or normal bacterial flora?
APMIS 116 (9): 785-790
PubMed Link

Meibom KL, Dubail I, Dupuis M, Barel M, Lenco J, Stulik J, Golovliov I, Sjöstedt A, Charbit A (2008)
The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice
Mol Microbiol 67 (6): 1384-1401
PubMed Link

Kelk P, Claesson R, Chen C, Sjöstedt A, Johansson A (2008)
IL-1beta secretion induced by Aggregatibacter (Actinobacillus) actinomycetemcomitans is mainly caused by the leukotoxin
Int J Med Microbiol 298 (5-6): 529-541
PubMed Link

Eliasson H, Olcen P, Sjöstedt A, Jurstrand M, Back E, Andersson S (2008)
Kinetics of the immune response associated with tularemia: comparison of an enzyme-linked immunosorbent assay, a tube agglutination test, and a novel whole-blood lymphocyte stimulation test
Clin Vaccine Immunol 15 (8): 1238-1243
PubMed Link

Conlan JW, Zhao X, Harris G, Shen H, Bolanowski M, Rietz C, Sjostedt A, Chen W (2008)
Molecular immunology of experimental primary tularemia in mice infected by respiratory or intradermal routes with type A Francisella tularensis
Mol Immunol 45 (10): 2962-2969
PubMed Link

Bönquist L, Lindgren H, Golovliov I, Guina T, Sjöstedt A (2008)
MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages
Infect Immun 76 (8): 3502-3510
PubMed Link

Waldenström J, Lundkvist A, Falk KI, Garpmo U, Bergström S, Lindegren G, Sjöstedt A, Mejlon H, Fransson T, Haemig PD, Olsen B (2007)
Migrating birds and tickborne encephalitis virus
Emerg Infect Dis 13 (8): 1215-1218
PubMed Link

Titball RW, Sjostedt A, Pavelka MS, Jr., Nano FE (2007)
Biosafety and selectable markers
Ann N Y Acad Sci 1105 405-417
PubMed Link

Sjöstedt A (2007)
Tularemia: history, epidemiology, pathogen physiology, and clinical manifestations
Ann N Y Acad Sci 1105 1-29
PubMed Link

Lindgren H, Shen H, Zingmark C, Golovliov I, Conlan W, Sjöstedt A (2007)
Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG
Infect Immun 75 (3): 1303-1309
PubMed Link


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