dNTPs and maintenance of genome stability
PI: Andrei Chabes, Professor
Department of Medical Biochemistry and Biophysics
The four dNTPs (dATP, dTTP, dCTP and dGTP) are the building blocks of DNA. A balanced supply and a correct overall concentration of dNTPs are key prerequisites for faithful genome duplication. Therefore, production of dNTPs is tightly regulated by multiple mechanisms. The concentration of dNTPs fluctuates during the cell cycle.
We are investigating (i) how the DNA damage checkpoint, a genome surveillance mechanism, regulates the concentration of dNTPs, and how dNTPs regulate the activation of the DNA damage checkpoint and (ii) how the imbalanced dNTP pools affect the fidelity of replication and how different replication errors are recognized and repaired.