UMU logo

Publications of the Chabes Group

Yu, C.H., Gan, H.Y., Serra-Cardona, A., Zhang, L., Gan, S.L., Sharma, S., Johansson, E., Chabes, A., Xu, R.M. and Zhang, Z.G. (2018) A mechanism for preventing asymmetric histone segregation onto replicating DNA strands. Science 361(6409), 1386-+.

van Mourik, P.M., de Jong, J., Sharma, S., Kavsek, A., Chabes, A. and Chang, M. (2018) Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae. G3-Genes Genomes Genetics 8(8), 2551-2558.

Peng, X.P., Lim, S., Li, S.B., Marjavaara, L., Chabes, A. and Zhao, X.L. (2018) Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites. PLoS Genet 14(1), 20.

Li, S.Q., Xu, Z.Y., Xu, J.W., Zuo, L.Y., Yu, C.H., Zheng, P., Gan, H.Y., Wang, X.Z., Li, L.T., Sharma, S., Chabes, A., Li, D., Wang, S., Zheng, S.H., Li, J.B., Chen, X.F., Sun, Y.J., Xu, D.Y., Han, J.H., Chan, K.M., Qi, Z., Feng, J.X. and Li, Q. (2018) Rtt105 functions as a chaperone for replication protein A to preserve genome stability. Embo Journal 37(17), 16.

Lanz, M.C., Oberly, S., Sanford, E.J., Sharma, S., Chabes, A. and Smolka, M.B. (2018) Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling. Genes & Development 32(11-12), 822-835.

Kong, Z., Jia, S., Chabes, A.L., Appelblad, P., Lundmark, R., Moritz, T. and Chabes, A. (2018) Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry. Nucleic Acids Res 46(11), e66.

Coquel, F., Silva, M.J., Techer, H., Zadorozhny, K., Sharma, S., Nieminuszczy, J., Mettling, C., Dardillac, E., Barthe, A., Schmitz, A.L., Promonet, A., Cribier, A., Sarrazin, A., Niedzwiedz, W., Lopez, B., Costanzo, V., Krejci, L., Chabes, A., Benkirane, M., Lin, Y.L. and Pasero, P. (2018) SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature 557(7703), 57-+.

Bacal, J., Moriel-Carretero, M., Pardo, B., Barthe, A., Sharma, S., Chabes, A., Lengronne, A. and Pasero, P. (2018) Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage. Embo Journal 37(21), 18.

Wanrooij, P.H., Engqvist, M.K.M., Forslund, J.M.E., Navarrete, C., Nilsson, A.K., Sedman, J., Wanrooij, S., Clausen, A.R. and Chabes, A. (2017) Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired. Proceedings of the National Academy of Sciences of the United States of America 114(47), 12466-12471.

Schmidt, T.T., Reyes, G., Gries, K., Ceylan, C.U., Sharma, S., Meurer, M., Knop, M., Chabes, A. and Hombauer, H. (2017) Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis. Proceedings of the National Academy of Sciences of the United States of America 114(22), E4442-E4451.

Nystrom, K., Pettersson, G., Wanrooij, P.H., Brunet, S., Said, J., Ortolani, G., Waldenstrom, J., Adamek, L., Tang, K.W., Norberg, P., Chabes, A., Hellstrand, K., Norder, H. and Lagging, M. (2017) Inosine triphosphate pyrophosphatase enhances the effect of ribavirin on hepatitis C virus cell culture infection. JOURNAL OF HEPATOLOGY 66(1), S321-S321.

Maicher, A., Gazy, I., Sharma, S., Marjavaara, L., Grinberg, G., Shemesh, K., Chabes, A. and Kupiec, M. (2017) Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres. PLoS Genet 13(10), 22.

Kochenova, O.V., Bezalel-Buch, R., Tran, P., Makarova, A.V., Chabes, A., Burgers, P.M.J. and Shcherbakova, P.V. (2017) Yeast DNA polymerase zeta maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations. Nucleic Acids Research 45(3), 1200-1218.

Garzon, J., Rodriguez, R., Kong, Z., Chabes, A., Rodriguez-Acebes, S., Mendez, J., Moreno, S. and Garcia-Higuera, I. (2017) Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene 36(42), 5808-5818.

Gan, H.Y., Yu, C.H., Devbhandari, S., Sharma, S., Han, J.H., Chabes, A., Remus, D. and Zhang, Z.G. (2017) Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress. Molecular Cell 68(2), 446-+.

Watt, D.L., Buckland, R.J., Lujan, S.A., Kunkel, T.A. and Chabes, A. (2016) Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools. Nucleic Acids Research 44(4), 1669-1680.

Rentoft, M., Lindell, K., Tran, P., Chabes, A.L., Buckland, R.J., Watt, D.L., Marjavaara, L., Nilsson, A.K., Melin, B., Trygg, J., Johansson, E. and Chabes, A. (2016) Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance. Proceedings of the National Academy of Sciences of the United States of America 113(17), 4723-4728.

Kenigsberg, E., Yehuda, Y., Marjavaara, L., Keszthelyi, A., Chabes, A., Tanay, A. and Simon, I. (2016) The mutation spectrum in genomic late replication domains shapes mammalian GC content. Nucleic Acids Research 44(9), 4222-4232.

Williams, L.N., Marjavaara, L., Knowels, G.M., Schultz, E.M., Fox, E.J., Chabes, A. and Herr, A.J. (2015) dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase epsilon variants. Proceedings of the National Academy of Sciences of the United States of America 112(19), E2457-E2466.

Williams, J.S., Clausen, A.R., Lujan, S.A., Marjavaara, L., Clark, A.B., Burgers, P.M., Chabes, A. and Kunkel, T.A. (2015) Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific. Nature Structural & Molecular Biology 22(4), 291-U235.

Mertz, T.M., Sharma, S., Chabes, A. and Shcherbakova, P.V. (2015) Colon cancer-associated mutator DNA polymerase delta variant causes expansion of dNTP pools increasing its own infidelity. Proceedings of the National Academy of Sciences of the United States of America 112(19), E2467-E2476.

Jia, S., Marjavaara, L., Buckland, R., Sharma, S. and Chabes, A. (2015) Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection. Methods Mol Biol 1300, 113-121.

Earp, C., Rowbotham, S., Merenyi, G., Chabes, A. and Cha, R.S. (2015) S phase block following MEC1(ATR) inactivation occurs without severe dNTP depletion. Biology Open 4(12), 1739-1743.

Earp, C., Rowbotham, S., Marjavaara, L., Chabes, A. and Cha, R.S. (2015) Acute sensitivity of DNA replication to reduction in dNTP pools following Mec1ATR inactivation. Yeast 32, S56-S56.

Barfeld, S.J., Fazli, L., Persson, M., Marjavaara, L., Urbanucci, A., Kaukoniemi, K.M., Rennie, P.S., Ceder, Y., Chabes, A., Visakorpi, T. and Mills, I.G. (2015) Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. Oncotarget 6(14), 12587-12602.

Yu, C.H., Gan, H.Y., Han, J.H., Zhou, Z.X., Jia, S.D., Chabes, A., Farrugia, G., Ordog, T. and Zhang, Z.G. (2014) Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall. Molecular Cell 56(4), 551-563.

Yoshida, K., Bacal, J., Desmarais, D., Padioleau, I., Tsaponina, O., Chabes, A., Pantesco, V., Dubois, E., Parrinello, H., Skrzypczak, M., Ginalski, K., Lengronne, A. and Pasero, P. (2014) The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast. Molecular Cell 54(4), 691-697.

Rubinstein, L., Ungar, L., Harari, Y., Babin, V., Ben-Aroya, S., Merenyi, G., Marjavaara, L., Chabes, A. and Kupiec, M. (2014) Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups. Nucleic Acids Research 42(10), 6314-6325.

Lin, C.Y., Wu, M.Y., Gay, S., Marjavaara, L., Lai, M.S., Hsiao, W.C., Hung, S.H., Tseng, H.Y., Wright, D.E., Wang, C.Y., Hsu, G.S.W., Devys, D., Chabes, A. and Kao, C.F. (2014) H2B Mono-ubiquitylation Facilitates Fork Stalling and Recovery during Replication Stress by Coordinating Rad53 Activation and Chromatin Assembly. PLoS Genet 10(10), 17.

Domkin, V. and Chabes, A. (2014) Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins. Scientific Reports 4, 7.

Buckland, R.J., Watt, D.L., Chittoor, B., Nilsson, A.K., Kunkel, T.A. and Chabes, A. (2014) Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity. PLoS Genet 10(12), 8.

Williams, J.S., Smith, D.J., Marjavaara, L., Lujan, S.A., Chabes, A. and Kunkel, T.A. (2013) Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA. Molecular Cell 49(5), 1010-1015.

Tsaponina O and Chabes A (2013). Pre-activation of the genome integrity checkpoint increases DNA damage tolerance. Nucleic Acids Res.1–8. doi:10.1093/nar/gkt820.
PubMed Link

Hoch NC, Chen ES, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD and Heierhorst J (2013). Molecular basis of the essential s phase function of the rad53 checkpoint kinase. Mol Cell Biol, 33 (16): 3202-3213.
PubMed Link

Williams JS, Smith DJ, Marjavaara L, Lujan SA, Chabes A and Kunkel TA (2013). Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA. Mol Cell, 49 (5): 1010-1015.
PubMed Link

Gupta A, Sharma S, Reichenbach P, Marjavaara L, Nilsson AK, Lingner J, Chabes A, Rothstein R and Chang M (2013). Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools. Genetics.
PubMed Link

Sanchez A, Sharma S, Rozenzhak S, Roguev A, Krogan NJ, Chabes A and Russell P (2012). Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol, 32 (21): 4445-4454.
PubMed Link

Poli J, Tsaponina O, Crabbe L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A and Pasero P (2012). dNTP pools determine fork progression and origin usage under replication stress. EMBO J, 31 (4): 883-894.
PubMed Link

Davidson MB, Katou Y, Keszthelyi A, Sing TL, Xia T, Ou J, Vaisica JA, Thevakumaran N, Marjavaara L, Myers CL, Chabes A, Shirahige K and Brown GW (2012). Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. EMBO J, 31 (4): 895-907.
PubMed Link

Tsaponina O, Barsoum E, Astrom SU, Chabes A (2011)
Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools
PLoS Genet 7: e1002061
PubMed Link

Rossmann MP, Luo W, Tsaponina O, Chabes A, Stillman B (2011)
A common telomeric gene silencing assay is affected by nucleotide metabolism
Mol Cell 42: 127-136
PubMed Link

Kumar D, Abdulovic AL, Viberg J, Nilsson AK, Kunkel TA, Chabes A (2011)
Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
Nucleic Acids Res 39: 1360-1371
PubMed Link

Johansson E, Speck C, Chabes A (2011)
A top-down view on DNA replication and recombination from 9,000 feet above sea level
Genome Biol 12: 304
PubMed Link

Deem A, Keszthelyi A, Blackgrove T, Vayl A, Coffey B, Mathur R, Chabes A, Malkova A (2011)
Break-induced replication is highly inaccurate
PLoS Biol 9: e1000594
PubMed Link

Nick McElhinny SA, Watts BE, Kumar D, Watt DL, Lundström EB, Burgers PM, Johansson E, Chabes A, Kunkel TA (2010)
Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases
Proc Natl Acad Sci U S A 107: 4949-4954
PubMed Link

Nick McElhinny SA, Kumar D, Clark AB, Watt DL, Watts BE, Lundström EB, Johansson E, Chabes A, Kunkel TA (2010)
Genome instability due to ribonucleotide incorporation into DNA
Nat Chem Biol 6: 774-781
PubMed Link

Kumar D, Viberg J, Nilsson AK, Chabes A (2010)
Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
Nucleic Acids Res 38: 3975-3983
PubMed Link

Fasullo M, Tsaponina O, Sun M, Chabes A (2010)
Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants
Nucleic Acids Res 38: 1195-1203
PubMed Link

Sabouri N, Viberg J, Goyal DK, Johansson E, Chabes A (2008)
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
Nucleic Acids Res 36: 5660-5667
PubMed Link

Chabes A, Stillman B (2007)
Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae
Proc Natl Acad Sci U S A 104: 1183-1188
PubMed Link

Chabes AL, Bjorklund S, Thelander L (2004)
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region
J Biol Chem 279: 10796-10807
PubMed Link

Chabes A, Georgieva B, Domkin V, Zhao X, Rothstein R, Thelander L (2003)
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
Cell 112: 391-401
PubMed Link

Chabes A, Thelander L (2003)
DNA building blocks at the foundation of better survival
Cell Cycle 2: 171-173
PubMed Link

Saitoh S, Chabes A, McDonald WH, Thelander L, Yates JR, Russell P (2002)
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA
Cell 109: 563-573
PubMed Link

Domkin V, Thelander L, Chabes A (2002)
Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex
J Biol Chem 277: 18574-18578
PubMed Link


Hofer A, Steverding D, Chabes A, Brun R, Thelander L (2001)
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness
Proc Natl Acad Sci U S A 98: 6412-6416
PubMed Link

Zhao X, Chabes A, Domkin V, Thelander L, Rothstein R (2001)
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
EMBO J 20: 3544-3553
PubMed Link

Chabes A, Thelander L (2000)
Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks
J Biol Chem 275: 17747-17753
PubMed Link

Zhao X, Georgieva B, Chabes A, Domkin V, Ippel JH, Schleucher J, Wijmenga S, Thelander L, Rothstein R (2000)
Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality
Mol Cell Biol 20: 9076-9083
PubMed Link

Chabes A, Domkin V, Larsson G, Liu A, Graslund A, Wijmenga S, Thelander L (2000)
Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit
Proc Natl Acad Sci U S A 97: 2474-2479
PubMed Link

Chabes A, Domkin V, Thelander L (1999)
Yeast Sml1, a protein inhibitor of ribonucleotide reductase
J Biol Chem 274: 36679-36683
PubMed Link

footer all slides 2014-02-06


Copyright © 2019 by The Laboratory for Molecular Infection Medicine Sweden (MIMS). All rights reserved.