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Cell-autonomous immunity

Sixt Barbara small MPN pressbildPI: Barbara Susanne Sixt, Ph.D., assistant professor
Department of Molecular Biology
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

The Sixt lab strives to uncover the hid­den protective potential of pathogen-suppressed cellular defense path­ways, to identify the mo­lecular determinants of host de­fense and pathogenic countermeasures, and to find means to disturb their balance to the ben­efit of the host. Our main experimental model is the interaction of human cells with the obligate intracellular bacterial pathogen Chlamydia trachomatis.


Introducing MIMS-EMBL group leaders: interview with Barbara Sixt (Link to interview).

PostDoc project (Drug Discovery and Cell-Autonomous Immunity)

This project aims to identify and characterize small chemical compounds that can counteract growth of the obligate intracellular bacterial pathogen Chlamydia trachomatis either by activating cell-autonomous defense responses in infected cells or by repressing the pathogen’s ability to counteract these cellular defenses. The project is expected to provide deeper insights into mechanisms of host-pathogen interaction and to uncover starting points for the development of new host-directed or anti-virulence drugs.

Specific aims of the project include:

  • The development and optimization of an experimental protocol for high-throughput small compound screening.
  • The implementation of the screening and candidate validation.
  • The characterization of the mode of action of validated candidate compounds.

Link to application website

PhD and PostDoc projects

We are constantly seeking highly motivated students and post-docs who would like to join our team. If you are interested in applying state-of-the-art tools in mo­lecular genetics to debunk the power of cell-autonomous immunity, please send me your CV and a short letter of motivation (preferentially as single PDF file) (email: This email address is being protected from spambots. You need JavaScript enabled to view it.).



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