PI: Barbara Susanne Sixt, Ph.D., assistant professor
Department of Molecular Biology
The Sixt lab strives to uncover the hidden protective potential of pathogen-suppressed cellular defense pathways, to identify the molecular determinants of host defense and pathogenic countermeasures, and to find means to disturb their balance to the benefit of the host. Our main experimental model is the interaction of human cells with the obligate intracellular bacterial pathogen Chlamydia trachomatis.
Introducing MIMS-EMBL group leaders: interview with Barbara Sixt (Link to interview).
PostDoc project (Drug Discovery and Cell-Autonomous Immunity)
This project aims to identify and characterize small chemical compounds that can counteract growth of the obligate intracellular bacterial pathogen Chlamydia trachomatis either by activating cell-autonomous defense responses in infected cells or by repressing the pathogen’s ability to counteract these cellular defenses. The project is expected to provide deeper insights into mechanisms of host-pathogen interaction and to uncover starting points for the development of new host-directed or anti-virulence drugs.
Specific aims of the project include:
- The development and optimization of an experimental protocol for high-throughput small compound screening.
- The implementation of the screening and candidate validation.
- The characterization of the mode of action of validated candidate compounds.
PhD and PostDoc projects