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Publications Björn O. Schröder

Highlighted Publications

i) Schroeder BO, Birchenough GMB, Ståhlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F. Bifidobacteria or fiber protect against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe 23, 1-14. (2018) PMID29276171

ii) Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Nat. Acad. Sci. USA 113(48):13833-13838 (2016) PMID27849619

iii) Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat. Medicine 22, 1079–1089. (2016) PMID27711063

iv) Schroeder BO, Ehmann D, Precht J, Küchler R, Castillo PA, Berger J, Schaller M, Stange EF, and Wehkamp J. Human alpha-defensin 6 (HD-6) is an antimicrobial peptide. Muc. Immunol. 8(3), 661-671. (2015) PMID25354318

v) Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 469, 419-423. (2011) PMID21248850

 

All Publications

2020

Keipert S, Lutter D, Schroeder BO, Brandt D, Ståhlman M, Schwarzmayr T, Graf E, Fuchs H, de Angelis MH, Tschöp MH, Rozman J, Jastroch M. Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice. Nat Comm. 11(1):624. (2020) PMID32005798

2019

Stange EF & Schroeder BO. Microbiota and mucosal defense in IBD: an update. Expert Rev. Gastroenterol. Hepatol. 13(10):963-976. (2019) PMID31603356

Volk JK, Nyström EEL, van der Post S, Abad BM, Schroeder BO, Johansson Å, Svensson F, Jäverfelt S, Johansson MEV, Hansson GC, Birchenough GMH. The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function. J Exp Med. 216(11):2602-2618. (2019) PMID31420376

Birchenough GMB, Schroeder BO, Bäckhed F and Hansson, GC. Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes 10:2, 246-250. (2019) PMID30252606

Wendler J*, Schroeder BO*, Ehmann D, Koeninger L, Mailänder-Sánchez D, Lemberg C, Wanner S, Schaller S, Stange EF, Malek N, Weidenmaier C, LeibundGut-Landmann S, Wehkamp J. Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide. Sci. Rep. 6;9(1):3640 (2019) PMID30842543 (*contributed equally)

Schroeder BO. Fight them or feed them: how the intestinal mucus layer manages the gut microbiota. Gast. Report 7(1), 3-12 (2019) PMID30792861

2018

Wendler J, Ehmann D, Courth L, Schroeder BO, Malek NP, Wehkamp J. Bacterial periplasmic oxido-reductases are essential for the activity of oxidized human antimicrobial β-defensin 1. Infect. Immun. 86 (4), e00875-17 (2018) PMID29378796

Schroeder BO, Birchenough GMB, Ståhlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F. Bifidobacteria or fiber protect against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe 23, 1-14. (2018) PMID29276171

2016

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Nat. Acad. Sci. USA 113(48):13833-13838 (2016) PMID27849619

Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat. Medicine 22, 1079–1089. (2016) PMID27711063

2015

Hein KZ, Takahashi H, Tsumori T, Yasui Y, Nanjoh Y, Toga T, Wu Z, Grötzinger J, Jung S, Wehkamp J, Schroeder BO, Schroeder JM, Morita E. Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide. Proc. Nat. Acad. Sci. USA 112(42): 13039-44. (2015) PMID26438863

Schroeder BO, Ehmann D, Precht J, Küchler R, Castillo PA, Berger J, Schaller M, Stange EF, and Wehkamp J. Human alpha-defensin 6 (HD-6) is an antimicrobial peptide. Muc. Immunol. 8(3), 661-671. (2015) PMID25354318

2013

Nuding S, Gersemann M, Hosaka Y, Konietzny S, Schaefer C, Beisner J, Schroeder BO, Ostaff MJ, Saigenji K, Ott G, Schaller M, Stange EF, Wehkamp J. Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance. PLoS One 8(9):e73867. (2013) PMID24040100

Küchler R, Schroeder BO, Jaeger SU, Stange EF, Wehkamp J. Antimicrobial activity of high-mobility group box 2: a new function to a well-known protein. Antimicrob. Agents Chemother. 57(10):4782-93. (2013) PMID23877675

Jaeger SU, Schroeder BO, Meyer-Hoffert U, Fehr SN, Courth L, Gersemann M, Stange EF and Wehkamp J. Cell-mediated reduction of human β-defensin 1: A major role for mucosal thioredoxin. Muc. Immunol. 6(6),1179-90. (2013) PMID23571504

2012

Schroeder BO, Stange EF and Wehkamp J. Humanes Beta-Defensin 1: Aus der Defensive gelockt. Z. Gastroenterol. 50(11), 1171-1175. (2012) PMID23150110

Troge A, Scheppach W, Schroeder BO, Rund SA, Heuner K, Wehkamp J, Stange EF, Oelschlaeger TA. More than a marine propeller – the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus. Int. J. Med. Microbiol. 302(7-8), 304-314. (2012) PMID23131416

2011

Schroeder BO, Stange EF and Wehkamp J. Waking the wimp: Redox modulation activates human beta-defensin 1. Gut Microbes 2(4), 262-266. (2011) PMID21983064

Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 469, 419-423. (2011) PMID21248850

2009

Möndel M, Schroeder BO, Zimmermann K, Huber H, Nuding S, Beisner J, Fellermann K, Stange EF, Wehkamp J. Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Muc. Immunol. 2(2), 166-172. (2009) PMID19129752

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