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Reference Details
Park, H. S., Östberg, Y., Johansson, J., Wagner, E. G. and Uhlin, B. E. (2010), "Novel role for a bacterial nucleoid protein in translation of mRNAs with suboptimal ribosome-binding sites", Genes Dev, 24, 13: 1345-1350.

Abstract:
In Escherichia coli, the major nucleoid protein H-NS limits transcription by acting as a repressor or transcriptional silencer, presumably by its ability to close the looped chromosome domains in the nucleoid through DNA-protein-DNA bridging. Here, we demonstrate the direct involvement of H-NS as a positive factor stimulating translation of the malT mRNA. In vitro studies showed that H-NS facilitates a repositioning of the 30S preinitiation complex on the malT mRNA. H-NS stimulation of translation depended on the AU-rich -35 to -40 region of the mRNA. Several additional examples were found demonstrating a novel function for H-NS in translation of genes with suboptimal ribosome-binding sequences.

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