PostDoc project (Drug Discovery and Cell-Autonomous Immunity)
This projects aims to identify and characterize small chemical compounds that can counteract growth of the obligate intracellular bacterial pathogen Chlamydia trachomatis either by activating cell-autonomous defense responses in infected cells or by repressing the pathogen’s ability to counteract these cellular defenses. The project is expected to provide deeper insights into mechanisms of host-pathogen interaction and to uncover starting points for the development of new host-directed or anti-virulence drugs.
Specific aims of the project include:
- The development and optimization of an experimental protocol for high-throughput small compound screening.
- The implementation of the screening and candidate validation.
- The characterization of the mode of action of validated candidate compounds.
PhD and PostDoc projects