Are you a physicist, a mathematician, a programmer, or a technically savvy biologist? Want to see how far we model the most complex system (un)known to mankind? Our lab might be the place for you! Send your CV and tell us what you might want to do. Below are the two “archetypes” we are generally looking for. Don’t worry about not knowing everything, we will teach you along the ride! It is generally best to focus one one side (dry or wet) but you will be expected to dabble on both sides. You can’t analyze data for an experiment you don’t understand, and you shouldn’t design an experiment unless you have a plan for analyzing it.
If you are looking for a postdoc then we will together write an application for a fellowship. Though the budget may have space for another position in the meanwhile
Keywords: ATAC-seq, RNA-seq, metabolomics, proteomics, single-cell, bayesian statistics, molecular biology, cloning, tensorflow, transcription factors, lipids, viruses, HIV, T cells, immunology, infection models, circadian rhythm, cytokines
Typical computational biologist – focus on dry lab
This is an idealistic wishlist so don't be intimidated! You will develop the models, based on our data and data from others. You will suggest experiments and experimental design, to obtain the data the model requires. You should have a feel for designing models and/or know how to solve them. We will in particular work with sequence analysis, transcriptomics, ATAC, proteomics, metabolomics, single-cell and CRISPR. Basic knowledge of Bayesian statistics is very welcome. STAN may be useful. TensorFlow is likely to be used, and Python is likely the language of choice (but any programming language experience is already great). In terms of equations, you want to have an idea how to solve optimisation problems (such as for MLE), basic ODE, but more importantly, just how to deal with truly large amounts of data. Your basic linear algebra toolbox will be put to good use. At some point we expect you to have learned enough biology that can you ask interesting questions on your own.
Typical computational biologist – focus on wet lab
You will plan and perform the experiments. Ability to clone is of utmost importance, as is understanding the chemistry of frequently used sequencing based protocols (e.g. RNA-seq, ATAC-seq, ChIP-seq, and single-cell versions). If you have an interest in robotics we might be able to satisfy your appetite for some of the high-throughput experiments. We will work primarily in vitro, but mouse in vivo experience is handy. Attention to detail whenever needed is great, but expect very few routine experiments – we develop new methods all the time. You will be producing viruses and work with infection models.
You will of course take part in analysing and interpreting the data. An ability to ask biological questions, and answer them using the data, is expected. Basic R/Python skills are ideal, though for this position we are happy if you can do basic subsetting and plotting.
About the location:
Our lab is located at Department of Molecular Biology at Umeå University, and MIMS, a part of the Nordic EMBL Partnership for Molecular Medicine. This place has long been a centre of excellence for molecular genetics and pathogen research. Our group takes advantage of this, bringing mechanistic knowledge of disease up to modern scale with high-throughput biology. MIMS is administrating the National Doctoral Programme in Infections and Antibiotics (NDPIA) which organises course and conferences for the swedish network of young investigators. The programme is open for PhD-students and postdocs.
Umeå University is dedicated to providing creative environments for learning and research. More than 4 400 employees and 34 000 students have already chosen Umeå University.
Umeå is a vibrant town, largely due to the students – international as well as from all over Sweden. Some personal favourites include the Swedish cuisine (gastropubs and microbreweries), over 6 dance styles represented, one of Swedens largest ju-jutsu clubs (among other budo), indoor and outdoor climbing, winter sports, sailing club, etc … And not being Stockholm, a place to live is affordable. Oh, and don’t worry about the language. The local pub even runs their pub quiz in english, as is the case with many other social activities! For some news from Sweden, in english, try out The local.