A postdoc fellowship is available in the group of Ellen Bushell (http://www.mims.umu.se/groups/ellen-bushell.html ) at the Department of Molecular Biology at Umeå University, Sweden and Laboratory for Molecular Infection Medicine Sweden (MIMS), (www.mims.umu.se). MIMS is the Swedish node in the Nordic EMBL Partnership in Molecular Medicine.
Background: Malarial disease is caused when protozoan malaria parasites invade and grow within red blood cells. The ability of the parasite to cytoadhere and thereby sequester to organs is critical for the parasite to cause disease, and is in turn dependent on the export of a large number of parasite proteins. We investigate the role of exported proteins in host-parasite interactions during malaria infections. We work primarily with the rodent malaria parasite Plasmodium berghei, which uniquely allows us to study these interactions in vivo. We are now looking for a postdoctoral researcher to join our growing team
The project: In our lab we use high-throughput genetic screens, where we employ next generation sequencing to determine growth rates for individual mutants from complex pools of barcoded P. berghei mutants growing in the bloodstream of infected mice. This method can also be employed to quantify mutants in infected organs. This project will use barcode sequencing to explore the function of exported proteins in cytoadherance and sequestration.
The successful candidate: Applicants must hold a PhD at the time of recruitment. You will have experience in molecular biology including DNA handling and manipulation, and experience in in vitro cell culture, in vivo work or parasitology. You will be proficient in, or keen to learn, data analysis and visualization using statistical computing packages such as R. An enthusiasm for and knowledge of computer programming (using Python or Perl) is also desirable. You must speak and write fluently in English, and you should have excellent communication skills. You enjoy working as a member of a larger team, while capable of working independently and you are highly self-motivated.