Project: Inclusion damage and repair during infection with Chlamydia trachomatis
Many intracellular pathogens of clinical importance have evolved strategies to avoid host cellular defenses by hiding within pathogen-containing vacuoles (PCVs). One of these pathogens is Chlamydia trachomatis, the most common bacterial agent of blindness and sexually-transmitted diseases. In this project, we aim to exploit the novel genetic techniques for C. trachomatis in combination with state-of-the-art live cell imaging and genetic screening technologies to obtain a comprehensive understanding of factors that regulate the stability of the Chlamydia PCV (inclusion).
We are currently seeking students that would like to join our team to work on this project.