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Battling antibiotic resistance

Scientists from MIMS and UCMR contributed to the movie "Battling antibiotic resistance" produced by the Knut and Alice Wallenberg Foundation.

Meet Umeå scientists Felipe Cava, Maria Fällman, Fredrik Almqvist, Elisabeth Sauer-Eriksson and Jörgen Johansson and MIMS Board member Birgitta Henriques Normark and their research on new antimicrobial strategies to fight antibiotic resistance.

Movie published by the Knut and Alice Wallenberg Foundation, 20 February 2018.

Details of antibiotic resistance mechanisms revealed in hospital-acquired drug-resistant pathogens

Gemma Atkinson IMG 2401 562[2018-03-02] A new paper published by the research groups of Gemma Atkinson and Vasili Hauryliuk at Umeå University resolves years of uncertainty about how the widespread antibiotic resistance factors in the protein group ABCF family confer resistance to lincosamide antibiotics, often used in treatment of infections caused by staphylococci, streptococci and anaerobic bacteria.

Antibiotic resistance is one of the biggest threats to global health, food security, and development today and the new antimicrobial strategies are urgently needed. Scientists at the Umeå Centre for Microbial Research (UCMR) and at The Laboratory for Molecular Infection Medicine Sweden (MIMS) study therefore also antibacterial resistance mechanisms in order to develop new therapeutic strategies against resistant bacteria. The researchers solved recently a mystery in antibiotic resistance research and published their findings in the journal Nucleic Acids Research, which specialises in leading edge research into nucleic acids such as DNA and RNA, and the proteins with which they interact.

Read more: Details of antibiotic resistance mechanisms revealed in hospital-acquired drug-resistant pathogens

Vasili Hauryliuk honoured with Estonian National Research Award

[vasili hauryliuk 1402018-03-02] Congratulations to Vasili Hauryliuk, who was honored with the National Research Award in Chemistry and Molecular Biology 2018 of the Republic of Estonia on 20th of February in Tartu. Hauryliuk was awarded as one of seven members of a research team at UT Institute of Technology led by Tanel Tenson, professor of the technology of antimicrobial compounds. The team was awarded for the cycle of research works, “Mechanisms of antibiotic action and antibiotic resistance”. The other members in the awarded research team are: Arvi Jõers, Niilo Kaldalu, Karin Kogermann, Ülo Maiväli, Marta Putrinš, all UT Institute of Technology. 

Read more: Vasili Hauryliuk honoured with Estonian National Research Award

Two Nordic foundations support a network in Cryo-EM, a Nobel Prize–winning technology

Jacques Dubochet, Nobel Laureate in Chemistry 2017, visited the cryo-EM Facility at UCEM on 13 December 2017, together UCEM-Director Linda Sandblad and Lars-Anders Carlson, researcher at WCMM.A new Swedish-Danish research alliance wants to advance understanding of how biological molecules look and behave. With support from the Knut and Alice Wallenberg Foundation and the Novo Nordisk Foundation, scientists at four universities in Sweden and Denmark will join forces to create a Nordic network in cryoelectron microscopy, whose developers were awarded the 2017 Nobel Prize in Chemistry.

The CryoNet network will bring together experts in cryoelectron microscopy at universities in Aarhus, Copenhagen, Stockholm and Umeå. A Swedish- Danish partnership between the Knut and Alice Wallenberg Foundation and the Novo Nordisk Foundation will fund the network. Each foundation has awarded a grant of €1 million over 4 years for CryoNet.

Read more: Two Nordic foundations support a network in Cryo-EM, a Nobel Prize–winning technology

1st Arctic Meeting on Clinical Tuberculosis, Umeå 25-26 January, 2018

Artic Tbc Conference 25 26 JanWelcome to the Arctic Meeting on Clinical Tuberculosis, Umeå!
The first Arctic Meeting on Clinical Tuberculosis will take place at Norrland University Hospital and is organized by researchers at Umeå University, Infection Clinic / TB Centrum Norr and TBnet.

Registration (deadline 20 January 2018)
Registration form

Please visit ucmr.umu.se for preliminary programme.

Nobel Laureate Jacques Dubochet visits Umeå University

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NCMM Director to join Institute for Cancer Research at Oslo University

57 Kjetil Tasken speaker news[2017-11-09) Director of NCMM, Professor Kjetil Taskén, has been appointed as the Head and Director of Institute for Cancer Research Oslo University Hospital (OUH). Professor Taskén will start his new position on 1 January 2018. Kjetil is the founding Director of NCMM, and until September 2017 also held the speaker position for the Nordic EMBL Partnership for Molecular Medicine. Since starting as the Director of the Biotechnology Centre of Oslo in 2003, and becoming Director of NCMM in 2008, he has overseen the growth, evolution and merging of the two organisations into the highly successful research centre that exists today.

Read more: NCMM Director to join Institute for Cancer Research at Oslo University

MIMS and UCMR PI:s receive funding from the Swedish Research Council

[2017-11-03] Several Researchers at MIMS and UCMR are among 40 people at Umeå University who will receive funding from The Swedish Research Council (VR). In total VR funded 569 application out of 2904 applications for both for Medicine and Health and for Natural and Engineering Sciences. The Swedish Research Council published its decision on the two calls on October 26th and October 31st on the research council’s website (www.vr.se).

Read more: MIMS and UCMR PI:s receive funding from the Swedish Research Council

Lessons from bacteria: Novel antimicrobial strategies based on interspecies metabolic cooperation

20171017 Aliashkevich Cava Alvarez 562 2MIMS- scientist publish in the high-impact Journal of the International Society for Microbial Ecology, ISME.

An important survival strategy in bacteria is the release of toxic substances, which can attack and kill cells and other bacteria. One of these substances are D-amino acids, which are secreted to the environment at high concentrations by very diverse bacteria. D-amino acids interfere with the growth of neighboring competitors thereby improving the chances of producer species to colonize an specific niche. Felipe Cava's research group at The Laboratory for Molecular Infection Medicine Sweden (MIMS) studied the biological effects caused by distinct D-amino acids released by the causative agent of cholera, Vibrio cholerae. The study was performed in collaboration with Miguel A de Pedro, a former visiting professor at Umeå University and investigator at the Centro de Biología Molecular ‘Severo Ochoa’, CSIC in Madrid, Spain.

The scientists found that D-Arginine is a very potent and very broad growth inhibitor of many diverse bacterial species, including pathogenic ones such as Burkholderias, well known for their implication in pulmonary infections and their broad antibiotic resistance.

Read more: Lessons from bacteria: Novel antimicrobial strategies based on interspecies metabolic cooperation

Anna Överby Wernstedt receives Hagberg prize

Overby[171015] Karolinska Institutet informed today that the Ebba-Christina Hagberg Foundation decided to award Anna Överby Wernstedt with the foundation's award for 2017 for her biochemical studies of viral infections.
According to Sven and Ebba-Christina Hagberg Foundation's motivation, Anna Överby Wernstedt receives the award for "her biochemical studies of viral infections. Her work is fundamental for our understanding of how the body defends itself against invading viruses."
"It's wonderful to get this prize and I feel deeply honoured", says Anna Överby Wernstedt. "The prize is a welcome additional funding of my research"

Read more: Anna Överby Wernstedt receives Hagberg prize

Emmanuelle Charpentier:
MIMS is characterized by
ECharpentier about MIMS 2015 1

Emmanuelle Charpentier, Alumna at MIMS, now Director of the Max Planck Unit for the Science of Pathogens and Director of the Department of Regulation in Infection Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

Link to the Emmanuelle Charpentier Lab

footer all slides 2014-02-06


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