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VINNOVA funding for research on tuberculosis

Mikael Elofsson and Christer Larsson, researchers at Umeå University's departments for chemistry and molecular biology, were granted SEK 3.9 million by VINNOVA for a three-year research project to study new therapies against tuberculosis. The poject involves expertise in chemistry, and molecular infection biology and is a collaboration with scientists in Bangalore, India, headed by Tanjore Balganes, Open Source Drug Discovery, Council for Scientific and Industrial Research.

Read more on the webpage of Umeå University; in Swedish only)

Antibiotics may trigger bacterial resistance against immune defences - Sun Nynt Wai and colleagues publish in PLOS Pathogens

TEM of Vibrio cell small SNWFor the first time, scientists at Umeå University show how bacterial resistance to antimicrobial peptides in the immune defence may develop as the result of treatment with an antibiotic substance.

The rapid emergence antimicrobial resistance among pathogenic is a big medical and scientific challenge of our time. There is a need for development of new treatment strategies and such efforts require that the molecular mechanisms of bacterial resistance are understood.

Umeå University’s scientists professor Sun Nyunt Wai, professor Bernt Eric Uhlin and their colleagues at the Laboratory for Molecular Infection Medicine Sweden (MIMS) study the molecular mechanisms contributing to the survival and spread of Vibrio cholerae, the causative organism of cholera. This Gram-negative bacterium is responsible for many large epidemics of infectious disease that has killed millions of people. Cholera infections are getting more and more life-threatening as several bacterial variants already exist that are resistant against some antibacterial components of the innate human immune system.

During their growth Vibrio cholerae bacteria release small membrane vesicles from the outer membrane. They are filled with substances that may affect and damage the human host cells.

Read more: Antibiotics may trigger bacterial resistance against immune defences - Sun Nynt Wai and colleagues...

56,8 million SEK funding from Knut and Alice Wallenberg Foundation for infection research in Umeå

Important funding for MIMS and UCMR.

Knut and Alice Wallenberg Foundation considers two projects lead by MIMS scientists that they will lead to scientific breakthrough and assigned them with extraordinary funding.

The project "New drugs against viral infections of the respiratory tract and eyes" will receive 23,8 million SEK and has the long-term goal to identify the detailed mechanisms that viruses use to get into  a cell. The main applicant is Niklas Arnberg, professor and group leader at MIMS.

The second project will mainly study "New strategies to disarm bacteria" and receives 33 million SEK . Main applicant of this project is MIMS/UCMR group leader professor Sven Bergström, also head of the department of Molecular Biology.

Read more: 56,8 million SEK funding from Knut and Alice Wallenberg Foundation for infection research in Umeå

Andrei Chabes and Olga Tsaponina publish breakthrough article in Nucleic Acids Research

The journal Nucleic Acids Research published an article of the Andrei Chabes' group as a breakthrough article on September 17, 2013.

When treated with DNA - damaging drugs (chemotherapy) cells must activate special signaling pathways for the DNA repair. These signal paths have a similar structure in humans, other mammals and also in simpler organisms, such as baker's yeast .

Olga Tsaponina and Andrei Chabes at the Department of Medical Biochemistry and Biophysics, Umeå University, show that a pre-treatment of yeast cells with substances that produce a mild activation of these protective pathways, protects these cells when they are then subjected to a tougher treatment with DNA -damaging drugs (chemotherapy) .

- A similar pretreatment could possibly be used also to cancer patients to protect healthy cells during chemotherapy. In cancer cells, by contrast, these signaling pathways are destructed in order to enable unlimited growth.  These cells would therefore not be protected by this pretreatment says Andrei Chabes, lecturer at the Department of Medical Bichemistry and Biophysics and group leader at MIMS.

The journal Nucleic Acids Research selects only 2-3 percent of the magazine's best articles as a " Breakthrough Article" in terms of originality, significance and scientific excellence.

Original Publication:
O Tsaponina, A Chabes: Pre-activation of the genome integrity checkpoint increases DNA damage tolerance Nucleic Acids Research, 2013, 1–8. doi:10.1093/nar/gkt820
Fulltext for download (pdf)

Press release of published by Umeå University (in Swedish)
Webpage of Andrei Chabes' group at MIMS
Webpage of Andrei Chabes at the Department of Medical Biochemistry and Biophysics

ONE HEALTH SWEDEN- Symposium in Umeå, 7th Nov 2013

 One Health Sweden


One Health Sweden (www.onehealth.se) is a interdisciplinary network of scientists in Sweden which stimulates interdisciplinary collaborations to increase knowledge of the emergence, spread and effects of infectious diseases and antibiotic resistance in humans, domestic animals and wildlife.

The network invites to an information symposium on

Thursday 7th November 2013, 14.00 - 16.00
at Chemical Biological Centre (KBC), Lilla hörsalen
Organised by This email address is being protected from spambots. You need JavaScript enabled to view it.

Read more: ONE HEALTH SWEDEN- Symposium in Umeå, 7th Nov 2013

Introduction to high throughput screening - 2 ECTS

Introduction to high throughput screening - 2 ECTS

The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentations.

Participants can start at any time and study in their own paces since the course is entirely web-based with English course material consisting of text, figures, video lectures, review articles, and movies. The students study at their own places and examination will be carried out on request.


Registration

Read more: Introduction to high throughput screening - 2 ECTS

Candida albicans escapes from mouse neutrophils - publication of the Constantin Urban lab

Constantin Urban and his colleagues compared the interactions of C. albicans with neutrophil granulocytes from mice and humans. Their studies show that the human immune system is better to cope with fungal infections than the corresponding cells in mice, which are commonly used as a model to study fungal infections.

Press release from Umeå University (in Swedish)


Original publication in Journal of Leucocyte Biology
(Published online before print May 6, 2013, doi: 10.1189/jlb.0213063)

Editorial: Of Mice and Men—Yet Again, by Henry Rosén
(Published in doi:10.1189/jlb.0413187 August 2013, Journal of Leukocyte Biology vol. 94, no. 2: 210-212).

Webpage of Constantin Urban's lab "Antifungal Immunity"

Biomolecular NMR - A hands-on PhD course (2 ECTS)

Biomolecular NMR - A hands-on PhD course (2ECTS)

Organised by the NMR for Life at University of Gothenburg and Umeå University

Venue: Swedish NMR Centre, University of Gothenburg
Dates: 14-­‐18 Oct 2013
Target group: PhD students and researchers with projects involving protein characterization by NMR

Organizers:

• Vladislav Orekhov, Swedish NMR Centre, Univ. of Gothenburg
• Martin Billeter, Chem. and Mol. Biology, Univ. of Gothenburg
• Gerhard Gröbner, Umeå University, Sweden

Information: will be posted at http://www.nmr.gu.se/english/courses/

Registration
: by e-­‐mail to orov 'at' nmr.gu.se;  deadline -­‐ 1 Oct 2013; registration fee -­‐ none; number of participants is limited

Read more: Biomolecular NMR - A hands-on PhD course (2 ECTS)

Welcome to the MIMS UCMR Mini-Symposium 30th Sept 2013!

Place: Betula salen, building 6M, University Hospital Area

Welcome to interesting afternoon! Meet new post-docs and group leaders
The post-docs recruited through the first UCMR_MIMS call and the new MIMS group leaders will present their research. Bernt Eric Uhlin director of MIMS and UCMR will give an update over the newest developments at MIMS.

pdfFinal programme for download

Read more: Welcome to the MIMS UCMR Mini-Symposium 30th Sept 2013!

New Group leaders at MIMS

New MIMS group leaders:  Vasili Hauryliuk and Felipe Cava

vasili-hauryliuk 140From the beginning of this summer two additional excellent scientists are setting up their laboratories at MIMS, affiliated to the Department of Molecular Biology at Umeå University.
Vasili Hauryliuk, who most recently was a group leader and assistant professor at the University of Tartu in Estonia, will continue his research on the bacterial stringent response. He combines both experimental and in silico approaches to study the response of microorganisms to environmental stress. Stringent respons is involved in the regulation of bacterial virulence, antibiotic tolerance and biofilm formation. Better understanding of this adaptation of microorganisms is important for the development of specific inhibitors and new antimicrobial strategies.

Read more on the webpage of Vasili Hauryliuk


Felipe CavaBefore Felipe Cava joined MIMS, he was group leader and assistant professor at the Universidad Autonóma de Madrid in Spain. From 2013 he is, after nomination by Umeå University, one of the first Wallenberg Academy Fellows, in the long-term programme for young researchers funded by the Knut and Alice Wallenberg Foundation. Felipe Cava's research area is a very aggressive and original line focused on the diversity and plasticity of bacterial cell walls (primarily made of the murein exoskeleton) under environmental conditions, a topic of the highest relevance to properly understand bacterial relations with neighbouring organisms at all levels, from commensalism to pathogenesis.

Read more on the webpage of Felipe Cava

[2013-08-01]

NIB 2019 - Registration open!

NIB NDPIA

Battling antibiotic resistance

movie by Knut and Alice Wallenberg Foundation, with participation of scientists from MIMS and UCMR:
Or watch the original movie on:
https://kaw.wallenberg.org/

Research about infectious diseases:

Oliver Billker in movie of Knut and Alice Wallenberg Foundation:
Or watch the original movie on:
https://kaw.wallenberg.org/

footer all slides 2014-02-06


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