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56,8 million SEK funding from Knut and Alice Wallenberg Foundation for infection research in Umeå

Important funding for MIMS and UCMR.

Knut and Alice Wallenberg Foundation considers two projects lead by MIMS scientists that they will lead to scientific breakthrough and assigned them with extraordinary funding.

The project "New drugs against viral infections of the respiratory tract and eyes" will receive 23,8 million SEK and has the long-term goal to identify the detailed mechanisms that viruses use to get into  a cell. The main applicant is Niklas Arnberg, professor and group leader at MIMS.

The second project will mainly study "New strategies to disarm bacteria" and receives 33 million SEK . Main applicant of this project is MIMS/UCMR group leader professor Sven Bergström, also head of the department of Molecular Biology.

Read more: 56,8 million SEK funding from Knut and Alice Wallenberg Foundation for infection research in Umeå

Andrei Chabes and Olga Tsaponina publish breakthrough article in Nucleic Acids Research

The journal Nucleic Acids Research published an article of the Andrei Chabes' group as a breakthrough article on September 17, 2013.

When treated with DNA - damaging drugs (chemotherapy) cells must activate special signaling pathways for the DNA repair. These signal paths have a similar structure in humans, other mammals and also in simpler organisms, such as baker's yeast .

Olga Tsaponina and Andrei Chabes at the Department of Medical Biochemistry and Biophysics, Umeå University, show that a pre-treatment of yeast cells with substances that produce a mild activation of these protective pathways, protects these cells when they are then subjected to a tougher treatment with DNA -damaging drugs (chemotherapy) .

- A similar pretreatment could possibly be used also to cancer patients to protect healthy cells during chemotherapy. In cancer cells, by contrast, these signaling pathways are destructed in order to enable unlimited growth.  These cells would therefore not be protected by this pretreatment says Andrei Chabes, lecturer at the Department of Medical Bichemistry and Biophysics and group leader at MIMS.

The journal Nucleic Acids Research selects only 2-3 percent of the magazine's best articles as a " Breakthrough Article" in terms of originality, significance and scientific excellence.

Original Publication:
O Tsaponina, A Chabes: Pre-activation of the genome integrity checkpoint increases DNA damage tolerance Nucleic Acids Research, 2013, 1–8. doi:10.1093/nar/gkt820
Fulltext for download (pdf)

Press release of published by Umeå University (in Swedish)
Webpage of Andrei Chabes' group at MIMS
Webpage of Andrei Chabes at the Department of Medical Biochemistry and Biophysics

ONE HEALTH SWEDEN- Symposium in Umeå, 7th Nov 2013

 One Health Sweden

One Health Sweden ( is a interdisciplinary network of scientists in Sweden which stimulates interdisciplinary collaborations to increase knowledge of the emergence, spread and effects of infectious diseases and antibiotic resistance in humans, domestic animals and wildlife.

The network invites to an information symposium on

Thursday 7th November 2013, 14.00 - 16.00
at Chemical Biological Centre (KBC), Lilla hörsalen
Organised by This email address is being protected from spambots. You need JavaScript enabled to view it.

Read more: ONE HEALTH SWEDEN- Symposium in Umeå, 7th Nov 2013

Introduction to high throughput screening - 2 ECTS

Introduction to high throughput screening - 2 ECTS

The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentations.

Participants can start at any time and study in their own paces since the course is entirely web-based with English course material consisting of text, figures, video lectures, review articles, and movies. The students study at their own places and examination will be carried out on request.


Read more: Introduction to high throughput screening - 2 ECTS

Candida albicans escapes from mouse neutrophils - publication of the Constantin Urban lab

Constantin Urban and his colleagues compared the interactions of C. albicans with neutrophil granulocytes from mice and humans. Their studies show that the human immune system is better to cope with fungal infections than the corresponding cells in mice, which are commonly used as a model to study fungal infections.

Press release from Umeå University (in Swedish)

Original publication in Journal of Leucocyte Biology
(Published online before print May 6, 2013, doi: 10.1189/jlb.0213063)

Editorial: Of Mice and Men—Yet Again, by Henry Rosén
(Published in doi:10.1189/jlb.0413187 August 2013, Journal of Leukocyte Biology vol. 94, no. 2: 210-212).

Webpage of Constantin Urban's lab "Antifungal Immunity"

Biomolecular NMR - A hands-on PhD course (2 ECTS)

Biomolecular NMR - A hands-on PhD course (2ECTS)

Organised by the NMR for Life at University of Gothenburg and Umeå University

Venue: Swedish NMR Centre, University of Gothenburg
Dates: 14-­‐18 Oct 2013
Target group: PhD students and researchers with projects involving protein characterization by NMR


• Vladislav Orekhov, Swedish NMR Centre, Univ. of Gothenburg
• Martin Billeter, Chem. and Mol. Biology, Univ. of Gothenburg
• Gerhard Gröbner, Umeå University, Sweden

Information: will be posted at

: by e-­‐mail to orov 'at';  deadline -­‐ 1 Oct 2013; registration fee -­‐ none; number of participants is limited

Read more: Biomolecular NMR - A hands-on PhD course (2 ECTS)

Welcome to the MIMS UCMR Mini-Symposium 30th Sept 2013!

Place: Betula salen, building 6M, University Hospital Area

Welcome to interesting afternoon! Meet new post-docs and group leaders
The post-docs recruited through the first UCMR_MIMS call and the new MIMS group leaders will present their research. Bernt Eric Uhlin director of MIMS and UCMR will give an update over the newest developments at MIMS.

pdfFinal programme for download

Read more: Welcome to the MIMS UCMR Mini-Symposium 30th Sept 2013!

New Group leaders at MIMS

New MIMS group leaders:  Vasili Hauryliuk and Felipe Cava

vasili-hauryliuk 140From the beginning of this summer two additional excellent scientists are setting up their laboratories at MIMS, affiliated to the Department of Molecular Biology at Umeå University.
Vasili Hauryliuk, who most recently was a group leader and assistant professor at the University of Tartu in Estonia, will continue his research on the bacterial stringent response. He combines both experimental and in silico approaches to study the response of microorganisms to environmental stress. Stringent respons is involved in the regulation of bacterial virulence, antibiotic tolerance and biofilm formation. Better understanding of this adaptation of microorganisms is important for the development of specific inhibitors and new antimicrobial strategies.

Read more on the webpage of Vasili Hauryliuk

Felipe CavaBefore Felipe Cava joined MIMS, he was group leader and assistant professor at the Universidad Autonóma de Madrid in Spain. From 2013 he is, after nomination by Umeå University, one of the first Wallenberg Academy Fellows, in the long-term programme for young researchers funded by the Knut and Alice Wallenberg Foundation. Felipe Cava's research area is a very aggressive and original line focused on the diversity and plasticity of bacterial cell walls (primarily made of the murein exoskeleton) under environmental conditions, a topic of the highest relevance to properly understand bacterial relations with neighbouring organisms at all levels, from commensalism to pathogenesis.

Read more on the webpage of Felipe Cava


Carl-Henrik Heldin new Chairman of the Board of the Nobel Foundation

The board of directors of The Nobel Foundation elected at their annual meeting in May 2013 Carl-Henrik Heldin as new chairperson of the Board of the Nobelfoundation. MIMS congratulates Carl-Henrik Heldin for this new position and is very grateful that he also the chair of the MIMS Board.

Professor Hansson. Vice Chairman of the Board says in the press release of the Nobel Foundation:
“We are pleased that Carl-Henrik Heldin will become the new Chairman of the Nobel Foundation’s Board of Directors.( ...) Professor Heldin is one of Scandinavia’s most distinguished scientists and a world authority in molecular biology and cancer research. I am convinced that with his good reputation and high integrity, Carl-Henrik Heldin will do an outstanding job for the Nobel Prize”.

See the whole press release here

25 million SEK for a project to study and inhibit bacterial virulence

Infection research in Umeå will receive considerable funding from the Swedish Council for Strategic Research (SSF). Within the SSF programme Molecular mechanisms in the interplay between microorganisms/parasites and their hosts (man, domestic animals, plants and forest trees) in relation to disease, nine research projects will be supported with a total of SEK 225 million, one project is hosted by Umeå University. Under the leadership of Mikael Elofsson a joint project with Karolinska institute will receive SEK 25 million over the next five years. From Umeå is also Åke Forsberg involved in the project which will focus on substances to study and inhibit bacterial virulence.

Fredrik Almqvist is co-applicant in a second project lead by Birgitta Henriques-Normark, professor at Karolinska Institute in Stockholm and Linnaeus Visiting Professor at UCMR.

Read more in the press release on Umeå University's web page (in Swedish)

Read the press release from SSF (in Swedish)

footer all slides 2014-02-06

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