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DNA-damage causes immune reaction and inflammation and is linked to cancer development

Nelson Gekara[2015-02-17] For the first time scientists from Umeå University show the importance of DNA damage in fine tuning of our innate immune system and hence the ability to mount the optimal inflammatory response to infections and other biological dangers. The study is published on 17th February in the very prestigious international journal Immunity (CellPress).

The research group of Nelson Gekara within the Laboratory for Molecular Infection Medicine Sweden (MIMS) at Umeå University is interested in understanding how the innate immune system, our first line of defense is regulated and how defects in the immune system contribute to infectious and inflammatory diseases. Our immune system does not lie idle waiting to be attacked before it responds. Even in the absence of infections, our immune system is in a constant state of alert. Among the immune mediators that are constantly produced at low levels and which keep our immune system awake are a group of factors called type I interferon. A very delicate balance in the production of type I interferons is essential for health: insufficient production results in susceptibility to viral infections, while excessive production normally leads to autoimmune/inflammatory diseases.

Read more: DNA-damage causes immune reaction and inflammation and is linked to cancer development

Emmanuelle Charpentier on Radio Sweden: Two interviews

Emmanuelle Charpentier SRListen to a portrait of Emmanuelle Charpentier on Radio Sweden broadcasted on 7th of February 2015 16.35

in Science channel (P1, Vetenskap, "Forskarliv").

In an personal interview with Annika Östman, Radio Sweden, Emmanuelle Charpentier, talks about her bakground, her childhood and her career.

She mentions the advantages of coming to Umeå and working at MIMS.

Listen to the programme "forskarliv"

A second interview Emmanuelle Charpentier talks about her discoveries and her research.

Read the interview with Emmanuelle Charpentier on the webpage of Radio Sweden, Sveriges radio (published 5th of February 2015).

Listen to the interview (20 min)

Breakthrough Researcher from Umeå University broadcasted on BBC World News

Emmanuelle Charpentier breakthrough prize[20141121] A week ago, Emmanuelle Charpentier, Professor at Umeå University and Helmholtz Center for Infection Research, was honored with a very prestigious award in life sciences: The BREAKTHROUGH PRIZE. The prize was funded by renowned entrepreneurs of the Silicon Valley to highlight big achievements of scientists in the domains of mathematics, physics and life sciences to the public and the younger generation. The prize honors breakthroughs in fundamental science, which are the basis for more discoveries and improvements for human kind.

Read more: Breakthrough Researcher from Umeå University broadcasted on BBC World News

9.25 Mio SEK funding from Swedish Research Council to Andrei Chabes, Constantin Urban and Sun Nyunt Wai

Three MIMS group leadera funded by the Swedish Research Council's General call for application 2014:

Andrei Chabes, received 4 Mio SEK funding for his project "DNA byggstenar och genomets stabilitet" (DNA building blocks and genome stability).

Constantin Urban will have his project "Identification of innate immune mechanisms in opportunistic mycoses and exploitation as antifungal therapies"  funded with 2.85 Mio SEK during the next years.

Sun Nyunt Wai received  funding of 2.4 Mio SEK funding for her project "Mechanisms and role of 'bacterial exosomes' Membrane vesicles from Gram-positive bacteria"

In total nine PIs at UCMR will be funded with 29,2 Mio SEK during the next four years: Fredrik Almqvist, Anna Arnqvist, Elisabeth Sauer-Eriksson, Sun Nyunt Wai, Mikael Elofsson, Anna Linusson, Matthew Francis, Andrei Chabes and Constantin Urban.

Se the press release from Swedish Research Council

Vasili Hauryliuk Ragnar Söderberg fellow in medicine 2014!

vasili-hauryliuk 140The Rangar Söderberg foundation is supporting promising young researchers "with innovative ideas and proven scientific excellence". As a Ragnar Söderberg Fellow, Vasili will receive a 5-year grant of 8 Million SEK.

Press release the Ragnar Söderberg foundation (in Swedish)
Press release of Umeå University (in Swedish)
Movie of the Ragnar Söderberg foundation with all seven awardees in 2014

Webpage of the Hauryliuk lab at MIMS at MIMS

[2014-10-15]

 

National doctoral programme on infections and antibiotics - registration open!

To all PhD students and postdocs active in infection biology or antibiotics research

The MIMS-affiliated National doctoral programme in Infections and Antibiotics - Registration open!

The new National doctoral programme in Infections and Antibiotics is open for all postdocs and PhD students active in research projects in the area of infection biology and antibiotics. After registration to the programme, young researchers will have access to courses, meetings and workshops organized by different universities in Sweden.

There will also be a possibility to apply for support for travel and accommodation costs for participation in activities at other universities than the "home" university. In addition, there will be an annual network meeting open to all registered students and postdocs.

We are currently establishing a web-site for the programme (mims-infectantibio.se). At this site you will find additional information about the programme, organization and contact persons together with information on future courses, workshops etc.

Welcome to register to the programme! The first registration deadline is set to 30 September.

Åke Forsberg
National Co-ordinator
090-7852526
076-7620512
This email address is being protected from spambots. You need JavaScript enabled to view it.

Anna Holmström
National Director of Studies
090-7852529
070-8188814
This email address is being protected from spambots. You need JavaScript enabled to view it.

www.mims.umu.se; mims-infectantibio.se

Interview with Emmanuelle Charpentier published in EMBLetc.

EMBLetc issue 80 thumbEMBL magazine EMBL etc. published in the summer 2014 issue an interview with MIMS groupleader Emmanuelle Charpentier.In the article by Claire Ainsworth Charpentier gives credits to The Nordic EMBL Partnership for Molecular Medicine which helped her to make her discoveries on CRISPR-Cas9.

Read the whole article in issue 80 of the EMBL etc. (page 40)

Swedish Research Council: Funding for UCMR Linnaeus Centre extended. 45 million SEK during second period

Umeå's infection research receives continued Linnaeus Centre funding with 45 million SEK during the second five-year period

Umeå University's successful infection research at Umeå Centre for Microbial Research (UCMR) will continue to receive Linnaeus Centre funding from the Swedish Research Council. This means continued funding with nine million SEK per year over a period of five years.

The Swedish Research Council and Formas has now completed the mid-term evaluation of the 20 Linnaeus environments, which received funding in 2008. One of these environments is the Umeå Centre for Microbial Research, UCMR.

"We are very pleased with the result of the evaluation and the continued support for UCMR", says Bernt Eric Uhlin, Scientific Coordinator for this Linneaus Centre.

The evalution states:
"UCMR is a leading centre nationally and internationally for chemical microbiology. This interdisciplinary centre brings together chemists, physicists and biologists. It is very well structured and has a remarkably successful training programme for young scientists. Their integration with the associated EMBL/MIMS structure has produced an impressive international centre. The GE Panel recommends continued funding at the existing level."

More information:
"Mid-term evaluation report of the 2008 Linnaeus Centres".

For further information:
Bernt Eric Uhlin, Professor at the Department of Molecular Biology, Scientific Coordinator of UCMR and Director of MIMS, Umeå University.
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Göran Gustafsson Prize for Emmanuelle Charpentier

charpentier emmanuelleEmmanuelle Charpentier receives Göran Gustafsson Prize for Molecular Biology 2014

Emmanuelle Charpentier, group leader at MIMS, is one of the five recipients of the Göran Gustafsson's prize 2014. She is being awarded the prize in Molecular Biology for her important discoveries of the mechanisms that control bacterial immunity. The discoveries have led to the development of a molecular tool for the modification of genes. The prize consists of 4.5 Million SEK in research funding and a 225.000 SEK personal award.

The Royal Swedish Academy of Sciences  press information, published on Monday 31 March 2014 (in Swedish)

Webpage of Emmanuelle Charpentier's research group

SEK 57 Million for new advanced electron microscopy - successful application by UCMR and MIMS scientists within a national network

Umeå University becomes national resource for advanced electron microscopy

[2014-03-27] Umeå University will be a national resource for advanced electron microscopy thanks to a contribution of SEK 57 million. Scientists across the country will be able to use the techniques for research, including detailed studies of microorganisms that cause infectious diseases.

- Sweden needs a national platform with a state-of-the-art electron microscopy facility to meet the future needs of visualization in medical, chemical and biological research. Umeå will now become a central node in a national network of research groups working together to improve the methods. This is not only a strength for our researchers, but also for the university as a whole, says Lena Gustafsson, Vice-Chancellor at Umeå University.

The Knut and Alice Wallenberg Foundation is investing SEK 37 million to develop the platform. The main applicants are Bernt Eric Uhlin and Linda Sandblad, Umeå Centre for Microbial Research (UCMR), who along with colleagues at Umeå University, Karolinska Institutet, Linköping University, Lund University and the Swedish University of Agricultural Sciences have developed plans for a national platform in Umeå.
Umeå University is also supporting the venture with another SEK 15 million. Moreover, the Kempe Foundations is investing SEK 5 million, which allows the acquisition of the most advanced and powerful equipment for electron microscopy.

Read more: SEK 57 Million for new advanced electron microscopy - successful application by UCMR and MIMS...

footer all slides 2014-02-06


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