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Publications of the Överby Group

Pena Carcamo, J.R., Morell, M.L., Vazquez, C.A., Vatansever, S., Upadhyay, A.S., Overby, A.K., Cordo, S.M. and Garcia, C.C. (2018) The interplay between viperin antiviral activity, lipid droplets and Junin mammarenavirus multiplication. Virology 514, 216-229.

Panayiotou, C., Lindqvist, R., Kurhade, C., Vonderstein, K., Pasto, J., Edlund, K., Upadhyay, A.S. and Overby, A.K. (2018) Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. J Virol 92(7).

Lund, H., Pieber, M., Parsa, R., Han, J.M., Grommisch, D., Ewing, E., Kular, L., Needhamsen, M., Espinosa, A., Nilsson, E., Overby, A.K., Butovsky, O., Jagodic, M., Zhang, X.M. and Harris, R.A. (2018) Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nature Communications 9, 13.

Kurhade C, Schreier S, Lee Y-P, Zegenhagen L, Hjertqvist M, Dobler G, Kröger A*, Överby AK* (2018). Correlation of disease severity in human tick-borne encephalitis and pathogenicity in mice. Accepted 7 May 2018 Emerging Infectious Diseases, MS# EID-17-1825

Lindqvist R*, Kurhade C*, Gilthorpe JD, Överby AK (2018). Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. J Neuroinflammation 2018 Mar 15;15(1):80. doi: 10.1186/s12974-018-1119-3.
(* contributed equal).
PubMed Link

Panayiotou C*, Lindqvist R*, Kurhade C, Vonderstein K, Pasto J, Edlund K, Upadhyay AS, Överby AK (2018). Viperin restricts Zika virus and tick-borne encephalitis virus replication by targeting NS3 for proteasomal degradation. J Virol 2018 Jan 10. pii: JVI.02054-17. doi: 10.1128/JVI.02054-17. [Epub ahead of print] (* contributed equal).
PubMed Link

Cárcamoa JRP, Morella ML, Vázquezb CA, Vatanseverc S, Upadhyay AS, Överby AK, Cordob SM, Garcíaa CC (2017). The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication, Virology, 2017 Dec 1;514:216-229. doi: 10.1016/j.virol.2017.10.012. [Epub ahead of print].
PubMed Link

Vonderstein K*, Nilsson E*, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, Pichlmair A, Lundmark R, Överby AK (2017). Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles, J Virol. 2017 Oct 18. pii: JVI.01751-17. [Epub ahead of print] (* contributed equal).
PubMed Link

Upadhyay AS, Stehling O, Panayiotou C, Rösser R, Lill R*, Överby AK* (2017). Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. J Biol Chem. 2017 Jun 14. pii: jbc.M117.780122.  (*Corresponding author and contributed equal)
PubMed Link

Asghar N, Lee Y-P, Nilsson E, Lindqvist R, Melik W, Kröger A, Overby AK*, and Johansson M* (2016) The role of poly(A) tract in replication and virulence of tick-borne encephalitis virus. Scientific Reports 2016, Dec 16;6:39265. doi: 10.1038/srep39265 (* contributed equally)
PubMed Link

Lindqvist R, Mundt F, Gilthorpe JD, Wölfel S, Gekara NO, Kröger A,, Överby AK. (2016). Fast Type I Interferon Response Protect Astrocytes from Flavivirus Infection and Virus-induced Cytopathic Effect. J Neuroinflammation 2016, Oct 24;13(1):277
PubMed Link

Dobler G, Bestehorn M, Antwerpen M, Överby-Wernstedt A (2016). Complete genome of a low-virulent Tick-borne encephalitis virus strain. Genome Announc. September/October 2016 4:e01145-16; doi:10.1128/genomeA.01145-16.
PubMed Link

Henningsson AJ, Lindqvist R, Norberg P, Lindblom P, Roth A, Forsberg P, Bergström T, Överby AK, Lindgren PE (2016). Human tick-borne encephalitis and characterization of virus from biting tick. Emerging Infectious Diseases 2016 Aug;22(8):1485-7. doi: 10.3201/eid2208.151962.
PubMed Link

Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A*, Överby AK* (2016). Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. J Neuroinflammation, 2016 Jan 27;13:22. doi: 10.1186/s12974-016-0487-9. (* Corresponding author and contributed equal)
PubMed Link

Islam MK, Baudin M, Eriksson J, Öberg C, Habjan M, Weber F, Överby AK, Ahlm C, Evander M (2016). High-throughput screening using a whole-cell virus replication reporter gene assay to identify inhibitory compounds against Rift Valley fever virus infection. J Biomol Screen 2016 Apr;21(4):354-62. doi: 10.1177/1087057115625184.
PubMed Link

Rezelj VV, Överby AK, Elliott RM. (2015)
Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonist.
J Virol. 2015 May;89(9):4849-56. doi: 10.1128/JVI.03511-14. Epub 2015 Feb 11.
PubMed Link

Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Överby AK, Kröger A. (2014)
Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses. J Virol. 2014 Nov;88(21):12202-12. doi: 10.1128/JVI.01215-14. Epub 2014 Aug 13.
PubMed Link

Asghar N, Lindblom P, Melik W, Lindqvist R, Haglund M, Forsberg P, Överby AK, Andreassen Å, Lindgren PE, Johansson M. (2014)
Tick-borne encephalitis virus sequenced directly from questing and blood-feeding ticks reveals quasispecies variance.
PLoS One. 2014 Jul 24;9(7):e103264. doi: 10.1371/journal.pone.0103264. eCollection 2014.
PubMed Link

Upadhyay AS, Vonderstein K, Pichlmair A, Stehling O, Bennett KL, Dobler G, Guo JT, Superti-Furga G, Lill R, Överby AK and Weber F (2013)
Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity
Cell Microbiol.2013 Nov 19. doi: 10.1111/cmi.12241. [Epub ahead of print]
PubMed Link

Verbruggen P, Ruf M, Blakqori G, Overby AK, Heidemann M, Eick D, Weber F (2011)
Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II
J Biol Chem 286 (5): 3681-3692
PubMed Link

Överby AK, Weber F (2011)
Hiding from intracellular pattern recognition receptors, a passive strategy of flavivirus immune evasion
Virulence 2 (3): 238-240
PubMed Link

Överby AK, Popov VL, Niedrig M, Weber F (2010)
Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles
J Virol 84 (17): 8470-8483
PubMed Link

Lozach PY, Mancini R, Bitto D, Meier R, Oestereich L, Överby AK, Pettersson RF, Helenius A (2010)
Entry of bunyaviruses into mammalian cells
Cell Host Microbe 7 (6): 488-499
PubMed Link

Huiskonen JT, Överby AK, Weber F, Grünewald K (2009)
Electron cryo-microscopy and single-particle averaging of Rift Valley fever virus: evidence for GN-GC glycoprotein heterodimers
J Virol 83 (8): 3762-3769
PubMed Link

Habjan M, Pichlmair A, Elliott RM, Överby AK, Glatter T, Gstaiger M, Superti-Furga G, Unger H, Weber F (2009)
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase
J Virol 83 (9): 4365-4375
PubMed Link

Habjan M, Penski N, Wagner V, Spiegel M, Överby AK, Kochs G, Huiskonen JT, Weber F (2009)
Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses
Virology 385 (2): 400-408
PubMed Link

Överby AK, Pettersson RF, Grünewald K, Huiskonen JT (2008)
Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus
Proc Natl Acad Sci U S A 105 (7): 2375-2379
PubMed Link

Överby AK, Pettersson RF, Neve EP (2007)
The glycoprotein cytoplasmic tail of Uukuniemi virus (Bunyaviridae) interacts with ribonucleoproteins and is critical for genome packaging
J Virol 81 (7): 3198-3205
PubMed Link

Överby AK, Popov V, Neve EP, Pettersson RF (2006)
Generation and analysis of infectious virus-like particles of uukuniemi virus (bunyaviridae): a useful system for studying bunyaviral packaging and budding
J Virol 80 (21): 10428-10435
PubMed Link

Lindgren L, Lindkvist M, Överby A, Ahlm C, Bucht G, Holmstrom A (2006)
Regions of importance for interaction of puumala virus nucleocapsid subunits
Virus Genes 33 (2): 169-174
PubMed Link

Flick K, Katz A, Överby A, Feldmann H, Pettersson RF, Flick R (2004)
Functional analysis of the noncoding regions of the Uukuniemi virus (Bunyaviridae) RNA segments
J Virol 78 (21): 11726-11738
PubMed Link

footer all slides 2014-02-06

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