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Publications of the Wai Group

Zhang, Z., Aung, K.M., Uhlin, B.E. and Wai, S.N. (2018) Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli. Scientific Reports 8, 11.

Nakao, R., Myint, S.L., Wai, S.N. and Uhlin, B.E. (2018) Enhanced Biofilm Formation and Membrane Vesicle Release by Escherichia coli Expressing a Commonly Occurring Plasmid Gene, kil. Frontiers in Microbiology 9, 18.

Dongre, M., Singh, B., Aung, K.M., Larsson, P., Miftakhova, R., Persson, K., Askarian, F., Johannessen, M., von Hofsten, J., Persson, J.L., Erhardt, M., Tuck, S., Uhlin, B.E. and Wai, S.N. (2018) Flagella-mediated secretion of a novel. Commun Biol 1, 59.

Codemo, M., Muschiol, S., Iovino, F., Nannapaneni, P., Plant, L., Wai, S.N. and Henriques-Normark, B. (2018) Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses. Mbio 9(2).

Askarian, F., Lapek, J.D., Jr., Dongre, M., Tsai, C.M., Kumaraswamy, M., Kousha, A., Valderrama, J.A., Ludviksen, J.A., Cavanagh, J.P., Uchiyama, S., Mollnes, T.E., Gonzalez, D.J., Wai, S.N., Nizet, V. and Johannessen, M. (2018) Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models. Front Microbiol 9, 262.

Tobias, J., Lebens, M., Wai, S.N., Holmgren, J. and Svennerholm, A.M. (2017) Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial antigens. Microb Pathog 105, 177-184.

Jers, C., Ravikumar, V., Lezyk, M., Sultan, A., Sjoling, A., Wai, S.N. and Mijakovic, I. (2017) The Global Acetylome of the Human Pathogen Vibrio cholerae V52 Reveals Lysine Acetylation of Major Transcriptional Regulators. Front Cell Infect Microbiol 7, 537.

Bitar, A., De, R., Melgar, S., Aung, K.M., Rahman, A., Qadri, F., Wai, S.N., Shirin, T. and Hammarstrom, M.L. (2017) Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera. Plos One 12(3), e0173817.

Song, T., Duperthuy, M. and Wai, S.N. (2016) Sub-Optimal Treatment of Bacterial Biofilms. Antibiotics-Basel 5(2).

Resch, U., Tsatsaronis, J.A., Le Rhun, A., Stuebiger, G., Rohde, M., Kasvandik, S., Holzmeister, S., Tinnefeld, P., Wai, S.N. and Charpentier, E. (2016) A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus. Mbio 7(6).

Mondal, A., Tapader, R., Chatterjee, N.S., Ghosh, A., Sinha, R., Koley, H., Saha, D.R., Chakrabarti, M.K., Wai, S.N. and Pal, A. (2016) Cytotoxic and Inflammatory Responses Induced by Outer Membrane Vesicle-Associated Biologically Active Proteases from Vibrio cholerae. Infect Immun 84(5), 1478-1490.

Karah, N., Dwibedi, C.K., Sjostrom, K., Edquist, P., Johansson, A., Wai, S.N. and Uhlin, B.E. (2016) Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates. Antimicrobial Agents and Chemotherapy 60(3), 1801-1818.

Aung, K.M., Sjöström, A.E., von Pawel-Rammingen, U., Riesbeck, K., Uhlin, B.E. and Wai, S.N. (2016) Naturally Occurring IgG Antibodies Provide Innate Protection against Vibrio cholerae Bacteremia by Recognition of the Outer Membrane Protein U. J Innate Immun 8(3), 269-283.

Vanhove, A.S., Duperthuy, M., Charriere, G.M., Le Roux, F., Goudenege, D., Gourbal, B., Kieffer-Jaquinod, S., Coute, Y., Wai, S.N. and Destoumieux-Garzon, D. (2015) Outer membrane vesicles are vehicles for the delivery of Vibrio tasmaniensis virulence factors to oyster immune cells. Environmental Microbiology 17(4), 1152-1165.

Sjöstrom, A.E., Sandblad, L., Uhlin, B.E. and Wai, S.N. (2015) Membrane vesicle-mediated release of bacterial RNA. Scientific Reports 5.

Sabharwal, D., Song, T., Papenfort, K. and Wai, S.N. (2015) The VrrA sRNA controls a stationary phase survival factor Vrp of Vibrio cholerae. Rna Biology 12(2), 186-196.

Ruhal, R., Antti, H., Rzhepishevska, O., Boulanger, N., Barbero, D.R., Wai, S.N., Uhlin, B.E. and Ramstedt, M. (2015) A multivariate approach to correlate bacterial surface properties to biofilm formation by lipopolysaccharide mutants of Pseudomonas aeruginosa. Colloids Surf B Biointerfaces 127, 182-191.

Rompikuntal, P.K., Vdovikova, S., Duperthuy, M., Johnson, T.L., Ahlund, M., Lundmark, R., Oscarsson, J., Sandkvist, M., Uhlin, B.E. and Wai, S.N. (2015) Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae. Plos One 10(7), 22.

Kunsmann, L., Ruter, C., Bauwens, A., Greune, L., Gluder, M., Kemper, B., Fruth, A., Wai, S.N., He, X., Lloubes, R., Schmidt, M.A., Dobrindt, U., Mellmann, A., Karch, H. and Bielaszewska, M. (2015) Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain. Sci Rep 5, 13252.

Kunsmann, L., Rueter, C., Bauwens, A., Greune, L., Glueder, M., Kemper, B., Fruth, A., Wai, S.N., He, X., Lloubes, R., Schmidt, M.A., Dobrindt, U., Mellmann, A., Karch, H. and Bielaszewska, M. (2015) Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain. Scientific Reports 5.

Kim, D.K., Lee, J., Kim, S.R., Choi, D.S., Yoon, Y.J., Kim, J.H., Go, G., Nhung, D., Hong, K., Jang, S.C., Kim, S.H., Park, K.S., Kim, O.Y., Park, H.T., Seo, J.H., Aikawa, E., Baj-Krzyworzeka, M., van Balkom, B.W., Belting, M., Blanc, L., Bond, V., Bongiovanni, A., Borras, F.E., Buee, L., Buzas, E.I., Cheng, L., Clayton, A., Cocucci, E., Dela Cruz, C.S., Desiderio, D.M., Di Vizio, D., Ekstrom, K., Falcon-Perez, J.M., Gardiner, C., Giebel, B., Greening, D.W., Gross, J.C., Gupta, D., Hendrix, A., Hill, A.F., Hill, M.M., Nolte-'t Hoen, E., Hwang, D.W., Inal, J., Jagannadham, M.V., Jayachandran, M., Jee, Y.K., Jorgensen, M., Kim, K.P., Kim, Y.K., Kislinger, T., Lasser, C., Lee, D.S., Lee, H., van Leeuwen, J., Lener, T., Liu, M.L., Lotvall, J., Marcilla, A., Mathivanan, S., Moller, A., Morhayim, J., Mullier, F., Nazarenko, I., Nieuwland, R., Nunes, D.N., Pang, K., Park, J., Patel, T., Pocsfalvi, G., Del Portillo, H., Putz, U., Ramirez, M.I., Rodrigues, M.L., Roh, T.Y., Royo, F., Sahoo, S., Schiffelers, R., Sharma, S., Siljander, P., Simpson, R.J., Soekmadji, C., Stahl, P., Stensballe, A., Stepien, E., Tahara, H., Trummer, A., Valadi, H., Vella, L.J., Wai, S.N., Witwer, K., Yanez-Mo, M., Youn, H., Zeidler, R. and Gho, Y.S. (2015) EVpedia: a community web portal for extracellular vesicles research. Bioinformatics 31(6), 933-939.

Karah, N., Samuelsen, O., Zarrilli, R., Sahl, J.W., Wai, S.N. and Uhlin, B.E. (2015) CRISPR-cas subtype I-Fb in Acinetobacter baumannii: evolution and utilization for strain subtyping. Plos One 10(2), e0118205.

Edwin, A., Persson, C., Mayzel, M., Wai, S.N., Ohman, A., Karlsson, B.G. and Sauer-Eriksson, A.E. (2015) Structure of the N-terminal domain of the metalloprotease PrtV from Vibrio cholerae. Protein Science 24(12), 2076-2080.

Duperthuy, M., Uhlin, B.E. and Wai, S.N. (2015) Biofilm Recruitment of Vibrio cholera by Matrix Proteolysis. Trends in Microbiology 23(11), 667-668.

Yamamoto, S., Mitobe, J., Ishikawa, T., Wai, S.N., Ohnishi, M., Watanabe, H. and Izumiya, H. (2014) Regulation of natural competence by the orphan two-component system sensor kinase ChiS involves a non-canonical transmembrane regulator in Vibrio cholerae. Molecular Microbiology 91(2), 326-347.

Wieser, A., Storz, E., Liegl, G., Peter, A., Pritsch, M., Shock, J., Wai, S.N. and Schubert, S. (2014) Efficient quantification and characterization of bacterial outer membrane derived nano-particles with flow cytometric analysis. International Journal of Medical Microbiology 304(8), 1032-1037.

Thay, B., Damm, A., Kufer, T.A., Wai, S.N. and Oscarsson, J. (2014) Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-kappa B Activation. Infection and Immunity 82(10), 4034-4046.

Song, T., Sabharwal, D., Gurung, J.M., Cheng, A.T., Sjostrom, A.E., Yildiz, F.H., Uhlin, B.E. and Wai, S.N. (2014) Vibrio cholerae Utilizes Direct sRNA Regulation in Expression of a Biofilm Matrix Protein. Plos One 9(7).

Enow, C.O., Oscarsson, J., Zlatkov, N., Westermark, M., Duperthuy, M., Wai, S.N. and Uhlin, B.E. (2014) Elevated recombinant clyA gene expression in the uropathogenic Escherichia coli strain 536, a clue to explain pathoadaptive mutations in a subset of extraintestinal E. coli strains. BMC Microbiol 14, 216.

Elluri, S., Enow, C., Vdovikova, S., Rompikuntal, P.K., Dongre, M., Carlsson, S., Pal, A., Uhlin, B.E. and Wai, S.N. (2014) Outer membrane vesicles mediate transport of biologically active Vibrio cholerae cytolysin (VCC) from V. cholerae strains. Plos One 9(9), e106731.

Edwin, A., Grundstrom, C., Wai, S.N., Öhman, A., Stier, G. and Sauer-Eriksson, A.E. (2014) Domain isolation, expression, purification and proteolytic activity of the metalloprotease PrtV from Vibrio cholerae. Protein Expression and Purification 96, 39-47.

Thay B, Wai SN and Oscarsson J (2013). Staphylococcus aureus alpha-Toxin-Dependent Induction of Host Cell Death by Membrane-Derived Vesicles. PLoS One, 8 (1): e54661.
PubMed Link

Valeru SP, Wai SN, Saeed A, Sandström G, Abd H (2012)
ToxR of Vibrio cholerae affects biofilm, rugosity and survival with Acanthamoeba castellanii
BMC Res Notes 5 33
PubMed Link

Rompikuntal PK, Thay B, Khan MK, Alanko J, Penttinen AM, Asikainen S, Wai SN, Oscarsson J (2012)
Perinuclear localization of internalized outer membrane vesicles carrying active cytolethal distending toxin from Aggregatibacter actinomycetemcomitans
Infect Immun 80 (1): 31-42
PubMed Link

Ishikawa T, Sabharwal D, Bröms J, Milton DL, Sjöstedt A, Uhlin BE, Wai SN (2012)
Pathoadaptive conditional regulation of the type VI secretion system in Vibrio cholerae O1 strains
Infect Immun 80 (2): 575-584
PubMed Link

Hedberg ME, Moore ER, Svensson-Stadler L, Hörstedt P, Baranov V, Hernell O, Wai SN, Hammarström S, Hammarström ML (2012)
Lachnoanaerobaculum a new genus in Lachnospiraceae; characterization of Lachnoanaerobaculum umeaense gen. nov., sp. nov., isolated from human small intestine, Lachnoanaerobaculum orale gen. nov., sp. nov., isolated from saliva and reclassification of Eubacterium saburreum (Prevot) Holdeman and Moore 1970 as Lachnoanaerobaculum saburreum comb. nov
Int J Syst Evol Microbiol Epub ahed of print /> PubMed Link

Ramstedt M, Nakao R, Wai SN, Uhlin BE, Boily JF (2011)
Monitoring surface chemical changes in the bacterial cell wall: multivariate analysis of cryo-x-ray photoelectron spectroscopy data
J Biol Chem 286 (14): 12389-12396
PubMed Link

Dongre M, Uhlin BE, Wai SN (2011)
Bacterial nanotubes for intimate sharing
Front Microbiol 2 108
PubMed Link

Bielig H, Rompikuntal PK, Dongre M, Zurek B, Lindmark B, Ramstedt M, Wai SN, Kufer TA (2011)
NOD-like receptor activation by outer membrane vesicles from Vibrio cholerae non-O1 non-O139 strains is modulated by the quorum-sensing regulator HapR
Infect Immun 79 (4): 1418-1427
PubMed Link

Syngkon A, Elluri S, Koley H, Rompikuntal PK, Saha DR, Chakrabarti MK, Bhadra RK, Wai SN, Pal A (2010)
Studies on a novel serine protease of a DeltahapADeltaprtV Vibrio cholerae O1 strain and its role in hemorrhagic response in the rabbit ileal loop model
PLoS One 5 (9): /> PubMed Link

Song T, Sabharwal D, Wai SN (2010)
VrrA mediates Hfq-dependent regulation of OmpT synthesis in Vibrio cholerae
J Mol Biol 400 (4): 682-688
PubMed Link

Olofsson A, Vallström A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, Arnqvist A (2010)
Biochemical and functional characterization of Helicobacter pylori vesicles
Mol Microbiol 77 (6): 1539-1555
PubMed Link

Weber B, Hasic M, Chen C, Wai SN, Milton DL (2009)
Type VI secretion modulates quorum sensing and stress response in Vibrio anguillarum
Environ Microbiol 11 (12): 3018-3028
PubMed Link

Valeru SP, Rompikuntal PK, Ishikawa T, Vaitkevicius K, Sjöling A, Dolganov N, Zhu J, Schoolnik G, Wai SN (2009)
Role of melanin pigment in expression of Vibrio cholerae virulence factors
Infect Immun 77 (3): 935-942
PubMed Link

Talyzina NM, Ingvarsson PK, Zhu J, Wai SN, Andersson A (2009)
Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains
Appl Environ Microbiol 75 (11): 3808-3812
PubMed Link

Song T, Wai SN (2009)
A novel sRNA that modulates virulence and environmental fitness of Vibrio cholerae
RNA Biol 6 (3): 254-258
PubMed Link

Sjöström A, Sondén B, Müller C, Rydström A, Dobrindt U, Wai S, Uhlin B (2009)
Analysis of the sfaX(II) locus in the Escherichia coli meningitis isolate IHE3034 reveals two novel regulatory genes within the promoter-distal region of the main S fimbrial operon
Microb Pathog 46 (3): 150-158
PubMed Link

Ou G, Hedberg M, Hörstedt P, Baranov V, Forsberg G, Drobni M, Sandström O, Wai SN, Johansson I, Hammarström ML, Hernell O, Hammarström S (2009)
Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease
Am J Gastroenterol 104 (12): 3058-3067
PubMed Link

Lindmark B, Rompikuntal PK, Vaitkevicius K, Song T, Mizunoe Y, Uhlin BE, Guerry P, Wai SN (2009)
Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni
BMC Microbiol 9 220
PubMed Link

Ishikawa T, Rompikuntal PK, Lindmark B, Milton DL, Wai SN (2009)
Quorum sensing regulation of the two hcp alleles in Vibrio cholerae O1 strains
PLoS One 4 (8): e6734
PubMed Link

Aldick T, Bielaszewska M, Uhlin BE, Humpf HU, Wai SN, Karch H (2009)
Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin
Molecular Microbiology 71 (6): 1496-1508
PubMed Link

Vaitkevicius K, Rompikuntal PK, Lindmark B, Vaitkevicius R, Song T, Wai SN (2008)
The metalloprotease PrtV from Vibrio cholerae
FEBS J 275 (12): 3167-3177
PubMed Link

Song T, Mika F, Lindmark B, Liu Z, Schild S, Bishop A, Zhu J, Camilli A, Johansson J, Vogel J, Wai SN (2008)
A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles
Mol Microbiol 70 (1): 100-111
PubMed Link

Karched M, Ihalin R, Eneslätt K, Zhong D, Oscarsson J, Wai SN, Chen C, Asikainen SE (2008)
Vesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form
BMC Microbiol 8 18
PubMed Link

Galka F, Wai SN, Kusch H, Engelmann S, Hecker M, Schmeck B, Hippenstiel S, Uhlin BE, Steinert M (2008)
Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles
Infection and Immunity 76 (5): 1825-1836
PubMed Link

Demuth A, Aharonowitz Y, Bachmann TT, Blum-Oehler G, Buchrieser C, Covacci A, Dobrindt U, Emody L, van der Ende A, Ewbank J, Fernandez LA, Frosch M, Garcia-del Portillo F, Gilmore MS, Glaser P, Goebel W, Hasnain SE, Heesemann J, Islam K, Korhonen T, Maiden M, Meyer TF, Montecucco C, Oswald E, Parkhill J, Pucciarelli MG, Ron E, Svanborg C, Uhlin BE, Wai SN, Wehland J, Hacker J (2008)
Pathogenomics: An updated European Research Agenda
Infection Genetics and Evolution 8 (3): 386-393
PubMed Link

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