Present: Department of Experimental Medical Science at Lund University, Sweden.
Past: MIMS Group Leader (2013-2021)
Research topic: Ribosome-associated factors involved in stress responses and antibiotic resistance
Vasili's research interests are molecular mechanisms and evolution of ribosomal protein synthesis and its regulation. The lab is using a combination of biochemical, microbiological and next-generation sequencing approaches and supported by collaboration with structural and evolutionary biologists to tackle four highly complementary research directions:
- Structure-functional studies of ribosome-associated and ribosome-independent enzymes RelA-SpoT Homologue (RSH) enzymes controlling intracellular levels of alarmone nucleotide (p)ppGpp in bacteria; development of selective inhibitors of RSH enzymes
- Structure-functional studies of bacterial toxin-antitoxin systems
- Structure-functional studies of bacterial ABCF ATPases involved in translational regulation and antibiotic resistance
- Structure-functional studies of eukaryotic ABCF ATPase translation factors with a special focus on yeast Saccharomyces cerevisiae