Project: Many of the most significant pathogens have the capacity to invade human cells and to exploit the interior of their host cell as replicative niche. While human cells have powerful defense programs that can restrict the growth of such invaders, successful pathogens typically evolved to resist these attacks. In the Sixt Lab, we believe that a profound understanding of the molecular basis of this arms race could pave the way for innovative therapeutics that can fight pathogens by unleashing the host cell-intrinsic defenses. Specifically, we strive to explore cell-autonomous immunity and evasion mechanisms during infection with the obligate intracellular bacterial pathogen Chlamydia trachomatis, and we seek ways to manipulate the balance to the benefit of the host.
We are currently seeking a PostDoc and a PhD student for a project that will apply state-of-the-art tools in molecular genetics, microscopy, and high-throughput genetic screening to determine the role of the Chlamydia-containing vacuole in counteracting cell-autonomous immunity.
Credit for image: Barbara Sixt, MIMS, Umeå University. Human cell infected with Chlamydia trachomatis.
Continue to read for all details on how to apply!
Environment: The Sixt Lab is part of the Laboratory for Molecular Infection Medicine Sweden (MIMS) at Umeå University (located in Umeå, Sweden). MIMS is the Swedish Node of the Nordic EMBL Partnership for Molecular Medicine and a part of UCMR (Umeå Centre for Microbial Research), which provides a stimulating, collaborative, and highly international research environment with excellent access to modern research facilities. The city Umeå itself combines a rich cultural life with exceptional closeness to nature and is particularly welcoming to internationals.
Qualifications: PhD: The ideal candidate must have a master degree in molecular biology (or equivalent). Previous lab experience in molecular biology, cell biology, and/or infection biology is a strong merit. Practical experience in human cell culture and fluorescence microscopy will be particularly beneficial. PostDoc: The ideal candidate must have a PhD degree in infection biology, cell biology, or microbiology (or equivalent). Previous research experience in the field of infection biology, in particular related to intracellular bacterial pathogens and/or cell-autonomous immunity, is a strong merit. Moreover, expertise in fluorescence microscopy applications (confocal microscopy, high resolution microscopy, and/or live cell imaging), and/or experience in implementing genetic screens will be highly beneficial. General: Candidates should be passionate about science, willing to take on scientific and technical challenges, and committed to highest quality research. Candidates are expected to be proficient in written and spoken English, to work as part of an interactive team, to participate in the mentoring of less experienced team members, and in particular to have the capacity to individually develop and drive a research project.
Project duration: PhD: 4 years, PostDoc: 2 years (with possibility for further prolongation depending on satisfactory performance). Starting date: preferentially March to mid 2021 (can be negotiated)
To find out more about the lab and our research, please visit our website: http://www.sixtlab.org (please also visit the sites of MIMS (http://www.mims.umu.se) and Umeå University (http://www.umu.se/en))
Please note that a formal application will be required through the official university recruitment system at a later stage.