A two-year postdoctoral fellowship is available to conduct structural studies of RNA virus replication in the group of Lars-Anders Carlson at Umeå University, Sweden
It is a collaborative project between three labs in Umeå: lab of Anna Överby Wernstedt, Richard Lundmark and Lars-Anders Carlson, with the postdoc working in the Carlson lab at the Department of Medical Biochemistry and Biophysics, Umeå University, Sweden. All three researchers are associated with various departments at Umeå University and with MIMS.
Short project description
Flaviviruses are a major group of pathogenic positive-sense RNA viruses including e.g. Dengue virus, Zika virus and tick-borne encephalitis virus. To replicate their genomes inside the infected cell, they depend on an elaborate remodelling of host-cell membranes which creates a virus-induced replication organelle on the endoplasmic reticulum membrane.
The deadline for the application is 9 July 2021. Continue reading to see more details and how to apply.
In this project, the postdoc will use biochemical methods and cryo-EM to study the structure and membrane remodelling properties of the proteins responsible for creating the flaviviral genome replication organelle. We offer a unique setup for this project in terms of a collaborative environment between four labs (three located in Umeå) studying tick-borne encephalitis virus from protein to organism level. The core of the project will be biochemistry and cryo-EM of viral replication proteins, and the postdoc will have ample measurement time on the local Titan Krios cryo-EM. Within the network the postdoc will also be able to draw on expertise from, and expand the project into, e.g. advanced cell biology and fluorescence microscopy, biosafety level 3 virology work, cryo-electron tomography of cells, and membrane reconstitution methods. We offer extensive opportunities for training in e.g. cryo-EM, cell biology and virology.
The application with all details and how to apply is available here: https://www.researchgate.net/job/952880_Postdoc_fellowship_in_cryo-EM_structural_studies_of_RNA_virus_replication
The deadline for the application is 9 July 2021. More information about the lab: http://www.carlsonlab.se/