A high profile review publication on antibiotic resistance from the Hauryliuk and Atkinson labs
Antibiotics bind to and corrupt the functioning of crucial elements of bacterial cells, such as the ribosome that synthesises proteins or RNA polymerase that reads genes to generate mRNA. To counter the action of antibiotics, bacteria have evolved numerous dedicated mechanisms of resistance. Commonly, these resistance mechanisms act by either destroying the antibiotic, pumping it out of the cell or permanently modifying the molecular target so it becomes immune to the antibiotic, e.g. by post-translational modification such as methylation.
In this review published in the influential journal Nature Reviews Microbiology, Umeå researchers Vasili Hauryliuk (also affiliated with Tartu University, Estonia) and Gemma C. Atkinson together with their collaborators Daniel N. Wilson (University of Hamburg, Germany) and Alex J. O’Neill (University of Leeds, UK) discuss an important and increasingly recognised type of antibiotic resistance: antibiotic resistance through target protection.