Endogenous danger signals in infection and inflammation
PI: Andrea Puhar, Ph.D.
Department of Molecular Biology
We study the role of endogenous danger signals (DAMPs), in particular extracellular ATP (eATP), during intestinal infection and inflammation. We wish to understand how elements of the gut and the intestinal bacteria - both pathogens and commensals - regulate and respond to the dynamic appearance and disappearance of eATP and how this impacts on development of disease.