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Publications of the Gekara Group

Panda, S. and Gekara, N.O. (2018) The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nature Communications 9, 13.

Webster, S.J., Brode, S., Ellis, L., Fitzmaurice, T.J., Elder, M.J., Gekara, N.O., Tourlomousis, P., Bryant, C., Clare, S., Chee, R., Gaston, H.J.S. and Goodall, J.C. (2017) Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection. Plos Pathogens 13(6), 23.

Putzova, D., Panda, S., Hartlova, A., Stulik, J. and Gekara, N.O. (2017) Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes. Cellular Microbiology 19(11), 11.

Gekara, N.O. (2017) DNA damage-induced immune response: Micronuclei provide key platform. Journal of Cell Biology 216(10), 2999-3001.

Lindqvist, R., Mundt, F., Gilthorpe, J.D., Woelfel, S., Gekara, N.O., Kroeger, A. and Overby, A.K. (2016) Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. Journal of Neuroinflammation 13.

Liew, L.P., Lim, Z.Y., Cohen, M., Kong, Z., Marjavaara, L., Chabes, A. and Bell, S.D. (2016) Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase. Cell Rep 17(6), 1657-1670.

Erttmann SF, Härtlova A, Sloniecka M, Raffi FA, Hosseinzadeh A, Edgren T, Rofougaran R, Resch U, Fällman M, Ek T, Gekara NO.
Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.
Immunity. 2016 Jul 19;45(1):106-18.
doi: 10.1016/j.immuni.2016.06.018. Epub 2016 Jul 12.
PubMed Link

Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A, Överby AK.
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
J Neuroinflammation. 2016 Jan 27;13:22. doi: 10.1186/s12974-016-0487-9.
PubMed Link

Panda S, Nilsson JA and Gekara NO.
Deubiquitinase MYSM1 regulates innate immunity through inactivation of TRAF3 and TRAF6 complexes.
Immunity. 2015 Oct 13;43(4)
PubMed Link

Härtlova A, Erttmann SF, Raffi FA, Schmalz AM, Resch U, Anugula S, Lienenklaus S, Nilsson LM, Kröger A, Nilsson JA, Ek T, Weiss S, Gekara NO.
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity.
Immunity. 2015 Feb 17;42(2):332-43. doi: 10.1016/j.immuni.2015.01.012.
PubMed Link

Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Överby AK, Kröger A.
Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses.
J Virol. 2014 Nov;88(21):12202-12. doi: 10.1128/JVI.01215-14. Epub 2014 Aug 13.
PubMed Link

Erttmann SF, Gekara NO, Fällman M.
Bacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism.
PLoS One. 2014 Jan 31;9(1):e87859. doi: 10.1371/journal.pone.0087859. eCollection 2014.
PubMed Link

Härtlova A, Link M, Balounova J, Benesova M, Resch U, Straskova A, Sobol M, Philimonenko A, Hozak P, Krocova Z, Gekara N, Filipp D, Stulik J.
Quantitative proteomics analysis of macrophage-derived lipid rafts reveals induction of autophagy pathway at the early time of Francisella tularensis LVS infection.
J Proteome Res. 2014 Feb 7;13(2):796-804. doi: 10.1021/pr4008656. Epub 2014 Jan 7.
PubMed Link

Viegas N, Andzinski L, Wu CF, Komoll RM, Gekara N, Dittmar KE, Weiss S, Jablonska J.
IFN-γ production by CD27⁺ NK cells exacerbates Listeria monocytogenes infection in mice by inhibiting granulocyte mobilization.  Eur J Immunol. 2013 Oct;43(10):2626-37. doi: 10.1002/eji.201242937. Epub 2013 Jul 25.
PubMed Link

Łyszkiewicz M, Zietara N, Rohde M, Gekara NO, Jablonska J, Dittmar KE, Weiss S (2011)
SIGN-R1+MHC II+ cells of the splenic marginal zone--a novel type of resident dendritic cells
J Leukoc Biol 89: 607-615
PubMed Link

Gekara NO, Zietara N, Geffers R, Weiss S (2010)
Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O
J Infect Dis 202: 1698-1707
PubMed Link

Dietrich N, Rohde M, Geffers R, Kroger A, Hauser H, Weiss S, Gekara NO (2010)
Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria
Proc Natl Acad Sci U S A 107: 8748-8753
PubMed Link

Dietrich N, Lienenklaus S, Weiss S, Gekara NO (2010)
Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments
PLoS One 5: e10250
PubMed Link

Zietara N, Lyszkiewicz M, Gekara N, Puchalka J, Dos Santos VA, Hunt CR, Pandita TK, Lienenklaus S, Weiss S (2009)
Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70
J Immunol 183: 1099-1109
PubMed Link

Lienenklaus S, Cornitescu M, Zietara N, Lyszkiewicz M, Gekara N, Jablonska J, Edenhofer F, Rajewsky K, Bruder D, Hafner M, Staeheli P, Weiss S (2009)
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo
J Immunol 183: 3229-3236
PubMed Link

Leschner S, Westphal K, Dietrich N, Viegas N, Jablonska J, Lyszkiewicz M, Lienenklaus S, Falk W, Gekara N, Loessner H, Weiss S (2009)
Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha
PLoS One 4: e6692
PubMed Link

Gekara NO, Dietrich N, Lyszkiewicz M, Lienenklaus S, Weiss S (2009)
Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition
J Infect Dis 199: 124-133
PubMed Link

Gekara NO, Weiss S (2008)
Mast cells initiate early anti-Listeria host defences
Cell Microbiol 10: 225-236
PubMed Link

Gekara NO, Groebe L, Viegas N, Weiss S (2008)
Listeria monocytogenes desensitizes immune cells to subsequent Ca2+ signaling via listeriolysin O-induced depletion of intracellular Ca2+ stores
Infect Immun 76: 857-862
PubMed Link

Gekara NO, Westphal K, Ma B, Rohde M, Groebe L, Weiss S (2007)
The multiple mechanisms of Ca2+ signalling by listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenes
Cell Microbiol 9: 2008-2021
PubMed Link

Bavdek A, Gekara NO, Priselac D, Gutierrez Aguirre I, Darji A, Chakraborty T, Macek P, Lakey JH, Weiss S, Anderluh G (2007)
Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O
Biochemistry 46: 4425-4437
PubMed Link

Gekara NO, Jacobs T, Chakraborty T, Weiss S (2005)
The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization
Cellular Microbiology 7: 1345-1356
PubMed Link

Gekara NO, Weiss S (2004)
Lipid rafts clustering and signalling by listeriolysin O
Biochemical Society Transactions 32: 712-714
PubMed Link

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