Ribosome-associated factors involved in stress responses and antibiotic resistance
PI: Vasili Hauryliuk, PhD, associate professor,
Ragnar Söderberg Fellow in Medicine 2014
Department of Molecular Biology
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Our research interests are molecular mechanisms and evolution of ribosomal protein synthesis and its regulation. The lab is using a combination of biochemical, microbiological and next-generation sequencing approaches and supported by collaboration with structural and evolutionary biologists to tackle three highly complementary research directions:
- Structure-functional studies of ribosome-associated and ribosome-independent enzymes RelA-SpoT Homologue (RSH) enzymes controlling intracellular levels of alarmone nucleotide (p)ppGpp in bacteria; development of selective inhibitors of RSH enzymes
- Structure-functional studies of bacterial ABCF ATPases involved in translational regulation and antibiotic resistance
- Structure-functional studies of eukaryotic ABCF ATPase translation factors with a special focus on yeast Saccharomyces cerevisiae
Our research is supported by the Swedish Research Council, Kempe foundation, Ragnar Söderberg foundation, Swedish Foundation for International Cooperation in Research and Higher Education, and Umeå University funds.
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