Ribosome-associated factors involved in stress responses and antibiotic resistance
PI: Vasili Hauryliuk, PhD, associate professor,
Ragnar Söderberg Fellow in Medicine 2014
Department of Molecular Biology
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Our research interests are molecular mechanisms and evolution of ribosomal protein synthesis and its regulation. The lab is using a combination of biochemical, microbiological and next-generation sequencing approaches and supported by collaboration with structural and evolutionary biologists to tackle three highly complementary research directions:
- Structure-functional studies of ribosome-associated and ribosome-independent enzymes RelA-SpoT Homologue (RSH) enzymes controlling intracellular levels of alarmone nucleotide (p)ppGpp in bacteria; development of selective inhibitors of RSH enzymes
- Structure-functional studies of bacterial ABCF ATPases involved in translational regulation and antibiotic resistance
- Structure-functional studies of eukaryotic ABCF ATPase translation factors with a special focus on yeast Saccharomyces cerevisiae
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