Postdoctoral position (2 years) in Åke Forsberg's lab - Targeting virulence mechanisms of Pseudomonas aeruginosa to develop novel sustainable antimicrobials
Targeting virulence mechanisms of Pseudomonas aeruginosa to develop novel sustainable antimicrobials
Antibiotics have been one the most important factors contributing to health and prosperity. However, their indiscriminate use has led to the emergence of multi-resistant "superbugs" and our ability to prevent and treat infectious diseases is today severely threatened. Development of novel sustainable antibacterial drugs with modes of action distinct from today's medicines has become a major priority. Our increased understanding of the often ingenious specific molecular mechanisms employed by many pathogens to establish infection opens a window of opportunity for development of novel antimicrobials.
We have initiated a research programme with five-year support from the Swedish foundation for Strategic Research (SSF) where we take a multidisciplinary approach involving molecular infection biology, structural biology and chemistry to explore molecular mechanisms of bacterial virulence using Pseudomonas aeruginosa as model system. Pseudomonas is a notorious pathogen with intrinsic as well as acquired antibiotic resistance that makes treatment a significant challenge. The ultimate goal is to identify and optimize small organic molecules that specifically block virulence mechanisms in Pseudomonas.
Qualifications and work description
We are looking for excellent and enthusiastic candidates with experience from studies of molecular virulence mechanism in important bacterial pathogens. Specifically we are looking for candidates with experience in bacterial genetics, mutagenesis, protein expression and purification and cell infection models and experience from studies of Pseudomonas is a merit. The candidate will be responsible for development and validation of biological assays for high throughput screening methods to identify and evaluate compounds blocking specific virulence mechanisms. The research will be conducted in a multidisciplinary research environment in close collaboration with chemists and structural biologists....