MIMS is establishing new research groups and is now recruiting Postdocs, Computational Biologists, Research Engineers and PhD students.
We are looking for qualified candidates interested in joining the highly interactive and multidisciplinary and international research environment for molecular infection medicine at Umeå University and two of our affiliated clinical research fellows at Lund University hospital and Karolinska Institutet.
Several Postdoctoral Fellowships, Research Engineer and Computational Biologist positions are available in the new laboratory of Oliver Billker (MIMS director from 1st October 2018). The projects are part of a major effort funded by the European Research Council to systematically identify parasite gene functions in malaria transmission.
Note! The deadline for these postdoc positions is 27th or 30 July 2018!
The following positions and fellowships are available:
Postdoctoral Fellowships in Experimental Genomics of Malaria Transmission are available for joining Oliver Billker’s (https://billkerlab.org/) new research team. Prospective PhD students are also encouraged to get in touch. A range of projects are available, such as:
- Systematic identification of fertility genes in malaria parasites. Using our unique ability to carry out forward genetics screens (Bushell et al., Cell, 2017), you will develop assays to identify experimentally all parasite genes involved in specific aspects of male or female fertility, which is essential for parasite transmission to the vector.
- Mechanisms of Plasmodium sex determination and sexual stage differentiation. Outgoing from a list of candidate nucleic acid binding proteins which have already emerged from a genetic screen, you will use ChIP, single cells RNAseq and protein interaction studies to elucidate the molecular mechanisms of development in a divergent eukaryote downstream of the master regulator, transcription factor ap2-g (Sinha et al., Nature, 2014).
- Single Cell Biology of Malaria Transmission. Using single cell transcriptomics (scRNAseq, e.g. Reid et al., eLife, 2018), you will carry out an in-depth analysis of developmental mutants, using their unique transcriptional signatures to propose genetic networks and mechanisms of parasite development during transmission.
- New Transmission Blocking Targets. The development of an effective vaccine to block malaria parasite infectivity to their mosquito vectors is considered a priority in ongoing efforts to eradicate malaria. Current targets undergoing clinical trials are all still from the pre-genomic era and pose significant challenges. With the advent of genetic screening technology in the rodent model parasite Plasmodium berghei (Bushell et al., 2017), it has now become possible for the first time to screen systematically for essential sexual stage antigens and evaluate their potential as future vaccine candidates.
- Mosquito Immunity. Our unpublished RNAseq analysis of thousands of single mosquito hemocytes has revealed new populations of immune cells of unknown function. You will use imaging and CRISPR-Cas9 mediated genome editing to reveal their roles in controlling insect immunity and vector competence.
- Evolution of sexual processes in a divergent eukaryote. You will exploit the position of malaria parasites in the tree of life to reveal the most conserved molecules in cellular processes involved in eukaryotic sexual reproduction, as well as discover some of the unique biology of apicomplexan parasites.
Read more (application information on the website of Umeå University)
Deadline 27 July 2018! (Start early fall 2018 (September/October)
Computational Biologist in the new Laboratory of Oliver Billker (new MIMS director from 1st October 2018): Experimental Genomics of Malaria Transmission
The projects form part of a major effort funded by the European Research Council to systematically identify parasite gene functions in malaria transmission. The positions are full time for two years.
We are building a new research team of experimentalists, analysts and modellers, who will collaborate in an interdisciplinary environment to address important questions of molecular infection medicine and pathogen genomics. We are now looking for an experienced computational biologist to design and analyse genomics experiments aimed at understanding the transmission biology of malaria parasites.
You will work collaboratively with the team to design biological experiments generating genome wide datasets, which will range from statistical analysis of genetic screens to single cell RNAseq. Where necessary, you will develop innovative analytical methods. Your work will contribute to the entire analysis workflow from pipelining primary RNAseq data processing and databases to bespoke systems/pathway/evolutionary level analysis. We are looking for an individual who can both lead on and contribute to publications and present data at international conferences.
Research Engineer in the Billkerlab:
Research Support for in vivo Malaria Model
We are building a new research group at MIMS to study the mosquito transmission of malaria parasites in a rodent model. The project forms part of a major effort funded by the European Research Council to systematically identify parasite gene functions in malaria transmission.
You will work with different members of the team to provide specialized support for work with our rodent malaria transmission model, including the breeding and dissection of mosquitoes, infection of cultured cells and maintaining parasites in mice and rats. You will also provide general laboratory management. The position is for two years.
Postdoctoral Fellowship and PhD Student Opportunities in the lab of Barbara Sixt:
Molecular Infection Biology & Cell-Autonomous Immunity
The recently established Sixt lab strives to apply state-of-the-art tools in molecular genetics, microscopy, high-throughput genetic and small compound screening, and next generation sequencing technology, to study the molecular basis of cell-autonomous immunity and bacterial evasion mechanisms during infection with obligate intracellular bacterial pathogens, such as Chlamydia trachomatis.
The postdoc project involves the development and implementation of a CRISPR/Cas9 screening approach to dissect the molecular composition of a recently identified novel pathway of programmed cell death induced during infection with the obligate intracellular bacterial pathogen Chlamydia trachomatis
Read more (Start: preferred start September 2018 )
Prospective PhD students are also encouraged to get in touch to discuss opportunities.
Postdoc in the lab of MIMS Clinical Research Fellow Lisa Påhlman, Lund University:
Acute and chronic airway infections in cystic fibrosis (CF)
The present project focuses on the CF pathogens Pseudomonas aeruginosa and Achromobacter xylosoxidans, with the aim to use molecular methods including genomics and cell infection models to characterise virulence factors involved in the establishment of acute and chronic airway infections. In particular, the role of Type 3 secretion and Twin-arginine translocation systems will be explored.
Read the complete advertisement (deadline 15 August 2018)
Postdoctoral Fellowship in Nelson Gekara's lab:
DNA Damage Response and Innate Immunity
We are interested in understanding the mechanisms that govern the regulation of the DNA damage response and Innate immune signaling pathways and how the breakdown of such regulation influences the outcome of infections, inflammatory diseases and genome instability - associated disorders (Panda S, Nilsson JA, Gekara NO. Immunity. 2015 Oct 20;43(4):647-59; Härtlova A, et al., Immunity. 2015 Feb 17;42(2):332-43 and Erttmann SF, et al., Immunity. 2016 Jul 19;45(1):106-18). We have identified new regulatory molecules involved in the regulation of the DNA damage response and the immune system. The goal of this project is to investigate their role and mechanisms in health and disease.
Postdoctoral Fellowship in the lab of Felipe Cava:
Peptidoglycan Diversity and Plasticity in Bacteria
We study cell wall biology and genetics in bacteria. We use high throughput analytical technologies to uncover novel determinants of cell wall homeostasis. The open project focuses on a genome wide peptidoglycan profiling in the model bacterium Vibrio cholerae.
In the study you will perform state of the art UPLC-MS assays coupled to chemometric tools, live microscopy and transposon-sequencing screenings amongst other biochemical, cell and molecular biology techniques.
Read more (Deadline: 30th of August, 2018)
We study the role of endogenous danger signals (DAMPs) such as extracellular ATP (eATP), during intestinal infection and inflammation. The open project aims at understanding how the gut microbiota and enteric pathogens regulate the intestinal eATP concentration and how this impacts the development of disease. You will perform molecular microbiology work including transposon screens and mutagenesis in combination with biochemical assays, protein purifications and in vitro/in vivo infections.
Read more about the Puhar lab
Contact for general questions about MIMS:
+46 73 0885731