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New potential target proteins for novel antibiotics discovered

Cava2022 Nature pic together

 

Press release – 30 November, 2022, Umeå, Sweden

New potential target proteins for novel antibiotics discovered

Bacteria are small but tough organisms, partly because their cells are enclosed by a protective cell wall skeleton. Professor Felipe Cava and his team at Umeå University in Sweden and collaborators at Harvard Medical School in the USA, have discovered long-sought proteins needed to maintain the bacterial cell wall structure. These proteins represent a very promising vulnerability for many bacteria that can be exploited by future antimicrobial compounds. The findings are published in Nature.

Read more: New potential target proteins for novel antibiotics discovered

André Mateus, MIMS Team Leader, receives ERC Starting Grant

Text by Nóra Lehotai.

Two researchers from Umeå University, André Nyberg (Department of Community Medicine and Rehabilitation) and André Mateus (Department of Chemistry), receive the prestigious ERC Starting Grant for emerging excellent scientists. Congratulations to André, new ERC laureate! 

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Read more: André Mateus, MIMS Team Leader, receives ERC Starting Grant

MIMS Symposium 2022: a platform for showcasing collaboration in basic, translational and clinical research

Written by Gretchen Repasky (Nordic EMBL Partnership) and Nóra Lehotai (MIMS)

MIMS welcomed its Executive Board and research community to the MIMS Symposium to share significant advances in research and its growing Baltic collaborations

On November 11, 2022, the MIMS Symposium highlighted MIMS research and Baltic collaborations for the local scientific community and the visiting MIMS Executive Board.

Opening MIMS Symposium reduced

Read more: MIMS Symposium 2022: a platform for showcasing collaboration in basic, translational and clinical...

How cryo-EM revealed the secrets of enterovirus replication

Written by Nóra Lehotai, Lars-Anders Carlson and Selma Dahmane

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How a virus hijacks a host cell to make new virus particles is a key question in the prevention and treatment of virus-caused diseases. Dr Selma Dahmane and Associate Professor Lars-Anders Carlson at Umeå University are the first and last authors of a freshly published paper in Nature Communications that sheds new light on this process. They show how new poliovirus particles are formed inside the infected cell thanks to the latest advancements in cryo-electron tomography. Poliovirus belongs to the group of enteroviruses, a big group of RNA viruses that also includes for example the common cold-causing rhinoviruses, or enterovirus D68 that can cause severe respiratory disease and paralysis in children. Polio itself has caused disease and death in humans for millennia, and the poliovirus was not long ago hoped to be eradicated. But the recent detection of poliovirus in London sewage, and a case of poliomyelitis in New York, has highlighted the difficulty in eliminating poliovirus even in developed countries.

Read more: How cryo-EM revealed the secrets of enterovirus replication

MIMS Scientific Symposium on 11 November 2022

We invite you to join the MIMS Scientific Symposium on 11 November 2022 in Aula Biologica at Umeå University campus!

A half day public scientific symposium organized by MIMS on 11 November 2022 in Aula Biologica at Umeå University campus. The Symposium starts at 9:00 and ends at 12:45, including a coffee break. Participants are then invited to join a lunch and mingle session at Brashörnan at Umeå University campus.

Read more: MIMS Scientific Symposium on 11 November 2022

The effects of COVID-19 on the nervous system are being studied in a new project

Original news article in Swedish written by Ola Nilsson. English translation by Anne-Marie Fors Connolly.

Fors Conolly Anne Marie 9878 220405 HKN 1

For five years, a European research project will investigate the long-term neurological and psychiatric symptoms following infection with SARS-CoV-2 that causes COVID-19, something that is becoming a societal problem. Umeå University is one of ten universities in seven countries that are part of the project.
Overall, the Neurocov project is about understanding the interaction between the central and peripheral nervous system and the inflammatory response that the immune system triggers during COVID-19 infection.

Picture: Anne-Marie Fors Connolly. Credit: Hans Karlsson.

Read more: The effects of COVID-19 on the nervous system are being studied in a new project

MIMS Spotlight Series: Meet Ionut Sebastian Mihai

Written by Nóra Lehotai and Ionut Sebastian Mihai.

The Industrial Doctoral School for Research and Innovation at Umeå University was established in 2008. Its goal is to create strong bonds between the private and public sectors by connecting doctoral students via shared projects and networking. Every doctoral student of the programme is supervised by a university researcher and mentored by an employee of an external party. I had a chat with Ionut Sebastian Mihai, who joined MIMS in 2019 as a doctoral student in the Henriksson group and is one of the students currently participating in this programme offered at Umeå University.

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Picture: Iounut Sebastian Mihai. Credit: Mattias Petterson.

Read more: MIMS Spotlight Series: Meet Ionut Sebastian Mihai

Nomination for the Wallenberg Academy Fellows program is open

Knut and Alice Wallenberg Foundation has set up a long-term program for young researchers: Wallenberg Academy Fellows.

The purpose of the Wallenberg Academy Fellows program is to give young researchers working conditions that enables them to focus on research and tackle difficult, long-term research questions.

Swedish universities are invited to nominate candidates for the program, which candidates then the Swedish Academies will evaluate and select the most promising researchers and the universities will then take long-term responsibility for these individuals.

Read more: Nomination for the Wallenberg Academy Fellows program is open

A new way to detect infection

Tadala et al Cell Reports 2022 1 forwebsite

Coloured electron microscopy image of a nascent plasma membrane ruffle enclosing a bacterium which invades an intestinal epithelial cell. Sample: Lalitha Tadala; Image acquisition: Ramón Cervantes-Rivera; Artistic rendering: Atin Sharma. MIMS, Umeå University.

Press release – 10 August 2022, Umeå, Sweden

A new way to detect infection

The immune system is under the constant challenge of specifically detecting dangerous microbes to remove them. Dr. Andrea Puhar and her team at The Laboratory for Molecular Infection Medicine Sweden (MIMS) at Umeå University, discovered that gut cells sense harmful bacteria through the mechanical force exerted on their cell surface during bacterial invasion. A protein called PIEZO1, which is able to sense mechanical signals, is necessary to detect invading bacteria. Activation of PIEZO1 during infection triggers a protective immune response. The study is now published in the scientific journal Cell Reports.

Read more: A new way to detect infection

MIMS Spotlight Series: Meet Debojyoti Das

Written by Nóra Lehotai and Debojyoti Das.

I had a chat with Debojyoti Das, a senior research assistant in the Bushell lab. He joined MIMS in January 2020 and since then he is balancing his time between different countries, traveling to visit his wife who has recently joined as an assistant professor in their home country, India.

Spotlight DD 1

Read more: MIMS Spotlight Series: Meet Debojyoti Das

Emmanuelle Charpentier took the Nobel Prize in Chemistry

Emmanuelle has been awarded jointly with Jennifer Doudna the 2020 Nobel Prize in Chemistry for discovering the groundbreaking CRISPR-Cas9 gene editing technology. She is a former group leader at MIMS, honorary doctor at Umeå University and former visiting professor at UCMR.

Movie by Knut and Alice Wallenberg Foundation (https://kaw.wallenberg.org/)

Battling antibiotic resistance

movie by Knut and Alice Wallenberg Foundation, with participation of scientists from MIMS and UCMR:
Or watch the original movie on:
https://kaw.wallenberg.org/

Research about infectious diseases:

Oliver Billker in movie of Knut and Alice Wallenberg Foundation:
Or watch the original movie on:
https://kaw.wallenberg.org/

footer all slides 2014-02-06


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