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A high profile review article from MIMS group leader Barbara S. Sixt on host cell death modulation by the bacterial pathogen Chlamydia

pic1A significant number of bacterial pathogens has the capacity to invade human cells and to exploit the interior of the host cell as growth niche. The bacteria reprogram host cellular functions to promote their growth and to suppress the intrinsic defense systems of the host cell. Pathogens have evolved to protect or compromise the viability of the host cell as their survival and life cycle within the cell depends on it. This interplay between host and microbe can be very complex. For instance, after a phase of growth, intracellular bacteria may actively induce cell death to promote their release and spread. While in other cases, the host cell may activate molecular suicide programs as defense response to restrict pathogen growth by removing the growth niche.

In a new review article published in FEMS Microbiology Reviews, MIMS group leader Barbara S. Sixt discusses the significance of this complex interplay and outstanding questions in the context of Chlamydia, a group of important pathogens causing for instance blinding eye infections, respiratory infections, and sexually transmitted diseases.

Illustration by Barbara S. Sixt, showing a viable cell infected with Chlamydia, which reside in a vacuole inside the host cell. Due to the occuring cell death, the host cell dies and releases the bacteria. 

Original publication:

Sixt BS (2020) Host cell death during infection with Chlamydia: a double-edged sword. FEMS Microbiol Rev

You can read the full article here.

About the author

Barbara S. Sixt joined Umeå University in 2018 to start a research group at the Laboratory for Molecular Infection Medicine Sweden. Her team uses innovative approaches to illuminate the power of host cell intrinsic defenses to discover new ways of combatting infectious diseases.

Affiliation: The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Department of Molecular Biology, Umeå University

Lab website: https://sixtlab.org/

Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

Emmanuelle Charpentier took the Nobel Prize in Chemistry

Emmanuelle has been awarded jointly with Jennifer Doudna the 2020 Nobel Prize in Chemistry for discovering the groundbreaking CRISPR-Cas9 gene editing technology. She is a former group leader at MIMS, honorary doctor at Umeå University and former visiting professor at UCMR.

Movie by Knut and Alice Wallenberg Foundation (https://kaw.wallenberg.org/)

Battling antibiotic resistance

movie by Knut and Alice Wallenberg Foundation, with participation of scientists from MIMS and UCMR:
Or watch the original movie on:
https://kaw.wallenberg.org/

Research about infectious diseases:

Oliver Billker in movie of Knut and Alice Wallenberg Foundation:
Or watch the original movie on:
https://kaw.wallenberg.org/

footer all slides 2014-02-06


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